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With the introduction of several COVID-19 vaccine candidates, vaccine efficacy has been widely reported; however, the meaning of vaccine efficacy is often unclear. The purpose of this commentary is to explain how vaccine efficacy is determined in the context of relative and absolute risk reduction...
000 deaths figure while the PR flacks at the table are working the vaccine angle. The crowd is getting restless. A man shouts, “Where is my flu shot? We’re all going to die!”
Protecting the next generation: what is the role of the duration of human papillomavirus vaccine-related immunity? This critical cost-effectiveness analysis warns that the duration of vaccine efficacy is the most critical parameter for successful vaccination of the young ... OP Günther,O Gina,N Mo...
Pneumococcal disease in the elderly: what is preventing vaccine efficacy? The effective prevention of Streptococcus pneumoniae infection has a renewed priority in an era in which the emergence of antibacterial-resistant strains h... JB Rubins,EN Janoff - 《Drugs & Aging》 被引量: 60发表: 2001年...
A candidate vaccine against SARS-CoV-2 might act against infection, disease, or transmission, and a vaccine capable of reducing any of these elements could contribute to disease control. However, the most important efficacy endpoint, protection against severe disease and death, is difficult to ...
Early-phase clinical trials focus on safety, not efficacy of vaccines. Therefore, far too many vaccines never get tested in the context of aged immune systems until Phase 2 and 3 clinical trials. The time to find out that a vaccine does not work well in the context of immunosenescence is ...
vaccine administration and composition factors can influence the development and perception of reactogenicity. The intent is to provide an overview of reactogenicity after vaccination to help the vaccine community, including healthcare professionals, in maintaining confidence in vaccines by promoting vaccination...
We concentrate on three questions: what is the nature of the immune response that contains the infection? How does this response fail? How could a vaccine enhance protective immunity so that it exceeds the efficacy of this natural response? 展开 ...
Efficacy of Acellular Pertussis Vaccine in Early Childhood After Household Exposure OBJECTIVE: To evaluate the efficacy of a three-dose primary vaccination with a diphtheria-tetanus tricomponent acellular pertussis vaccine against "typical... Schmitt,Heinz-J. - 《Jama》 被引量: 585发表: 1996年 Incre...