TheseSiglecsare proteins that recognize different versions of sialic acid, sugars that stud cells in the body. When the researchers genetically engineered mice to lack one of theSiglecs, encoded by a gene called Siglec-E, those mice died younger than mice that had all five intact genes. ...
so I would encourage everybody to get familiar with this word. Sialic acid is not the kind of sugar that we eat. Those are different sugars. This is a kind of sugar
Increasing evidence suggests that inflammatory and immune components in brain are important in Alzheimer’s disease (AD) and anti-inflammatory and immunotherapeutic approaches may be amenable to AD treatment. It is known that complement activation occurs
We previously showed that mouse ST8Sia II (STX) exhibits polysialic acid (PSA) synthase activity in vivo as well as in vitro (Kojima, N., Yoshida, Y., and Tsuji, S. (1995) FEBS Lett. 373, 119-122, 1995). In this paper, we reported that the neural cell adhesion molecule (NCAM)...
Our hypothesis, however, does not simply extend this idea to stem cell markers but claims that this is not a random process. It appears to be selective with respect to the proteins as well as with respect to the glycans involved. This raises several questions, for instance, what is the ...
Pal S, Tak YK, Song JM (2007) Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? A study of the Gram-negative bacterium Escherichia coli. Appl Environ Microbiol 73:1712–1720. https://doi.org/10.1128/AEM.02218-06 Article CAS Google Scholar Pan...
Sialic Acid Conjugate-Modified Cationic Liposomal Paclitaxel for Targeted Therapy of Lung Metastasis in Breast Cancer: What a Difference the Cation Content MakesDownload: Download high-res image (159KB) Download: Download full-size imageWenliang Sun...
RELATIONSHIP BETWEEN SIALIC ACID AND MICROVASCULAR COMPLICATIONS IN TYPE 2 DIABETES MELLITUS We excluded patients under 8 years of age, long standing diabetics with proteinuria ( greater than 7 years of IDDM and greater than 5 years for NIDDM), bilateral small echogenic or scarred kidneys (Kidney ...
The endothelial glycocalyx (EG) is the thin sugar-based lining on the apical surface of endothelial cells. It has been linked to the physiological functioning of the microcirculation and has been found to be damaged in critical illness and after acute ca
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