How does RAD51 affect DNA structure? What role does DNA helicase play in replication? Why is it important for DNA polymerase to proofread? How do proteins assist in DNA replication? Why are nucleic acids important? What is the role of proteins in a chromosome?
In BRCA1 carriers, no associations were observed with ATM, BARD1, CTIP, RAD50, RAD51, or TOPBP1. At BRIP1, an association was observed for one haplotype with a multiple testing corrected P (Pcorr) = 0.012, although no individual haplotype was significant. At MRE11, statistically ...
The lack of Rad52 foci in cycling G1 cells, however, does not necessarily indicate the absence of DSBs. Indeed, DSBs induced by X-rays in G1 are not associated with Rad52 foci [47] although Rad51 foci are observed [48]. It is likely that chromosomes with a G1-induced break do ...
How does RAD51 affect DNA structure? What is branched DNA? How does the structure of DNA allow cells to replicate? What makes one DNA molecule different from another? What determines the sequence of nucleotides in transfer RNA? What makes one nucleotide different from another? What is DNA stru...
Sawada K, Radjabi AR, Shinomiya N, Kistner E, Kenny H, Becker AR et al (2007) c-Met overexpression is a prognostic factor in ovarian cancer and an effective target for inhibition of peritoneal dissemination and invasion. Cancer Res 67:1670–1679 Article CAS PubMed Google Scholar Martin LP...
CDKN2A CEBPA DI53L2 EGFR EPCAM ERCC2 EZH2 FANCA FANCB FANCC FANCL FANCM FH FLCN KIT MAX MEN1 MET NF1 NF2 NSD1 PALB2 PRKAR1A PTCH1 PTEN RAD51C RUN XI SBDS SDHAF2 SDHB SMARCB1 STK11 5UFU TMEM127 WRN XPA XPC This chart shows all 98 cancer susceptible genes included in this new ...
RAD50, and NBS1 (MRN) complex [51], which is an important nuclease complex in the initiation of resection of the HR pathway. Use of the MRN complex in resolving DNA ends correlates with its evolutionally conserved role in DPC repair [7,52,53,54]. In particular, repair of antitumor age...
I previously reported about numerous cases of suspected (or even blatantly obvious) data manipulation at the Weizmann Institute of Science in Israel (here, here and here). Initially I wrongly assumed that the institute does not investigate misconduct evidence on principle. It turned out they do, ...
How does RAD51 affect DNA structure? How do genes control protein synthesis? What is a difference between DNA replication and RNA transcription? How does DNA control protein synthesis? How does DNA determine the traits of an organism? Why do all cells have the same ...
These factors include concentrated amounts of the tumour suppressor protein PML, as well as other regulatory proteins such as Sp100A, CBP, pRb, RAD51, Mre11, Daxx and p53 [205,206]. Several targets of this complex also include components of DDR pathways that are commonly activated upon ...