体外和体内实验均表明,过表达RAD51B-AS1促进的恶性生物学行为可以通过沉默RAD51B的表达部分或完全逆转。由此可见,RAD51B-AS1可促进卵巢癌的恶性生物学行为,并激活Akt/Bcl-2信号通路,这些作用可能与其正向调节RAD51B的表达有关。RAD51...
Methods: The data associated with RAD51-AS1 in OvCA were obtained from the Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) database. Relative expression of RAD51-AS1 was detected. Determination of cell proliferation, metastasis, and invasion was performed by cell counting, ...
2,3, Guoping Liu4, Junjun Qiu1,2,3, Ning Zhang1,2,3, Jingxin Ding1,2,3 & Keqin Hua1,2,3 Long non-coding RNA RAD51 antisense RNA 1 (RAD51-AS1, also known as TODRA) has been shown to be down-regulated by E2F1, a key cell cycle and apoptosis regulator, in breast cancer. ...
体外和体内实验均表明,过表达RAD51B-AS1促进的恶性生物学行为可以通过沉默RAD51B的表达部分或完全逆转.由此可见,RAD51B-AS1可促进卵巢癌的恶性生物学行为,并激活Akt/Bcl-2信号通路,这些作用可能与其正向调节RAD51B的表达有关.RAD51B-AS1有望作为一种新的分子生物标志物,用于卵巢癌不良预后的诊断和预测,并作为...
RAD51-AS1促进了卵巢癌细胞的增殖、迁移、侵袭和上皮间质转化 为了确定RAD51-AS1在卵巢癌(OvCA)中的生物学功能,作者建立了过表达RAD51-AS1的OVCAR3细胞(图S1A)。如预期,RAD51-AS1的过表达增强了OVCAR3细胞的增殖和集落形成能力(图2A和B)。此外,RAD51-AS1的过表达也显著增强了OVCAR3细胞的迁移和侵袭能力(图...
由此可见,RAD51B-AS1可促进卵巢癌的恶性生物学行为,并激活Akt/Bcl-2信号通路,这些作用可能与其正向调节RAD51B的表达有关。RAD51B-AS1有望作为一种新的分子生物标志物,用于卵巢癌不良预后的诊断和预测,并作为疾病管理的潜在治疗靶点。 关键词组:卵巢癌(OC);长链非编码RNA(LncRNA);转移;失巢凋亡...
RAD51-AS1YBX1Long noncoding RNA (lncRNA) is a new key regulatory molecule in the occurrence of osteoporosis, but its research is still in the primary stage. In order to study the role and mechanism of lncRNA in the occurrence of osteoporosis, we reannotated the GSE35956 datasets, compared...
Long non-coding RNA RAD51 antisense RNA 1 (RAD51-AS1, also known as TODRA) has been shown to be down-regulated by E2F1, a key cell cycle and apoptosis regulator, in breast cancer. Little is known regarding the role of RAD51-AS1 in disease. Here, we investigate the role of RAD51-...
本发明公开了一种分子标志物RAD51BAS1及其应用,RAD51BAS1为长链非编码RNA(ID:ENST00000554679.1),通过检测RAD51BAS1的表达水平来实现诊断卵巢癌的目的.本发明RAD51BAS1的表达水平在卵巢癌组织中,比在良性卵巢肿瘤组织中,明显增高,可用于制备诊断卵巢癌的产品与试剂盒;另外本发明RAD51BAS1可以影响卵巢癌增殖,迁移...
RAD51B-AS1.Cellular proliferation,metastasis,and apoptosis were detected using the cell counting kit-8(CCK-8),colony-formation,transwell,and flow cytometry assays.Mouse xenograft models were established for the detection of tumorigenesis.The results revealed that RAD51B-AS1 was significantly up...