Mitochondrial pharmacology 2012, Trends in Pharmacological Sciences Citation Excerpt : Mitochondrial oxidative phosphorylation is particularly sensitive to ATP demand through respiratory control, the rapid stimulation of respiratory chain activity in response to the lowering of the proton motive force caused by...
Application of the dynamic model to a dataset in- volving psychostimulant treatment suggested that relative to PLAC, low dose AMPH reduced gain prediction but increased gain prediction error. In the future, computational modeling may be combined with FMRI to better elucidate how pharmacology can ...
Kava is generally very well tolerated and safe, particularly in a water-based extract. However, in patients who have liver disease or who co-ingest alcohol or other potential hepatotoxins, there could be long-term liver damage. In addition, in the short term, ingestion with alcohol or other ...
Most drugs of abuse easily cross the placenta and can affect fetal brain development. In utero exposures to drugs thus can have long-lasting implications for brain structure and function. These effects on the developing nervous system, before homeostatic