Compartmentalized PKA signaling events are required for synaptic tagging and capture during hippocampal late-phase long-term potentiation pharmacological activation of the cAMP/PKA pathway, which can potentially affect all synapses within the neuron, is not impaired by inhibition of PKA ... T Huang,CB...
However, there is a reduction in the number of functional AMPA receptors, and both somatic and synaptic glutamatergic currents are reduced.85–87 A number of studies have shown deficient long-term potentiation in hippocampal slices from Gria1− / − mice,84–86 although more recent studies ...
The present study evaluated whether nitric oxide (NO) synthesis blockade or potentiation (with Nω-nitro-l-arginine or N-acetyl-l-cysteine, respectively) m... Francisco J Fenoy and Jerónimo Tornel and Marı́a Isabel Madrid and Erica López and Miguel Garcı́a-Salom - 《American Jou...
Mereu G, M Fa, L Ferraro, R Cagiano, T Antonelli, M Tattoli, V Ghiglieri, S Tanganelli, GL Gessa and V Cuomo (2003) Prenatal exposure to a cannabinoid agonist produces memory deficits linked to dysfunction in hippocampal long-term potentiation and glutamate release.Proc. Natl. Acad. Sci...
Borgland SL, Malenka RC, Bonci A (2004) Acute and chronic cocaine-induced potentiation of synaptic strength in the ventral tegmental area: electrophysiological and behavioral correlates in individual rats. J Neurosci 24(34):7482–7490.https://doi.org/10.1523/jneurosci.1312-04.2004 ...
Historically, the most widely used method to manipulate pathway function is behavioral pharmacology. For example, bilateral, site-specific intracranial administration of the combination of the GABAergic agonists, baclofen and muscimol, or of sodium channel blockers, such as local anesthetics, or tetrodot...
Transporter-dependent potentiation of mGluR EPSCs led to a dramatic increase in in- terneuron firing and enhanced inhibition of CA1 pyramidal neu- rons, suggesting that acute or prolonged disruption of transporter activity could lead to changes in network activity as a result of en- hanced ...
depressionin both animal models and humans [28]. In addition, the exposure to stress could alter the synaptic plasticity through lowering the threshold for long term potentiation induction in LHb [28], which may further disturb both the local neural microcircuits and long pr...
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In treating Mood Disorder in HUD patients, we must bear in mind the interactions (potentiation and side effects) between psychopharmacology, used substances and agonist opioid medications; the use of psychiatric medications as an anti-craving drug, and the possible use of agonist and antagonist ...