is because prior to this, we already tested this amongst ourselves, we knew the science of it, which is something that we study on the mice level at USC, so you can measure things like what’s called GABA potentiation in the brains of the mice, and then...
While secretory products, such as gut-derived metabolites may mediate gut-brain connection, there is also a direct connection via the vagus nerve [56]. The vagus nerve is the longest cranial nerve in the body and stretches from the large intestine to the brain. It is critical in involuntary ...
Mereu G, M Fa, L Ferraro, R Cagiano, T Antonelli, M Tattoli, V Ghiglieri, S Tanganelli, GL Gessa and V Cuomo (2003) Prenatal exposure to a cannabinoid agonist produces memory deficits linked to dysfunction in hippocampal long-term potentiation and glutamate release.Proc. Natl. Acad. Sci...
Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder that is characterized by abdominal pain and an altered defecation pattern. It affects between 5 and 20% of the general population and can seriously impact quality of life. The pathophysiology of IBS is rather complex an...
DCS's impact on NMDA receptors, especially those with NR2C subunits, is significant for fear learning and memory processes. It enhances fear extinction, memory consolidation, and visual recognition memory in animals, but its efficacy may decrease with repeated use. The drug's mechanism may be in...
If the latter takes the form of potentiation of recurrent synapses on principal cells, and depression of these on inhibitory interneurons, then the stage is set for synchronized bursting - if [Ca(2+)]o recovers sufficiently. Our hypothesis can be tested (in part) in patients, once it is ...
Flucytosine--what is its future? 来自 NCBI 喜欢 0 阅读量: 63 作者: MAM Viviani 摘要: J Antimicrob Chemother. 1995 Feb;35(2):241-4. Review 关键词: Humans Mycoses Amphotericin B Flucytosine Drug Therapy, Combination Drug Resistance, Microbial Forecasting ...
However, there is a reduction in the number of functional AMPA receptors, and both somatic and synaptic glutamatergic currents are reduced.85–87 A number of studies have shown deficient long-term potentiation in hippocampal slices from Gria1− / − mice,84–86 although more recent studies ...
When you have adopamine deficiency, Parkinson’s Disease can result. Consequently, a primary method of treatment for Parkinson’s involves the drug L-Dopa, which spurs dopamine production. While dopamine has also been linked to both ADHD and schizophrenia, its role in these disorders is still no...
Fear Conditioning and Long-term Potentiation in the Amygdala : What Really Is the Connection? The cellular mechanisms that underlie learning and memory formation remain one of the most intriguing unknowns about the mammalian brain. A plethora of exp... P Sah,RF Westbrook,A Lüthi - 《Annals ...