This is an overview of the current knowledge of adenosine receptor biology, from gene structure to expression, distribution, biochemical properties, pharmacological profiles, signalling and behavioural responses, focusing on receptor nomenclature and classification. CAS PubMed Google Scholar Fredholm, B. ...
How much do we know about drug handling by SLC and ABC drug transporters in children? Clin. Pharmacol. Ther. 94, 27–29 (2013). CAS PubMed Google Scholar Lopez-Lopez, E. et al. Polymorphisms in the methotrexate transport pathway: a new tool for MTX plasma level prediction in pediatric...
drug treatment with steroidal anti-inflammatory agents (NSAIDs), corticosteroid injections, and biologics [blocker of tumor necrosis factor (TNF)] have all been shown to be effective, while conventional disease modifying drugs (DMARDs) such as sulfasalazine and methotrexate seem to work mainly for ...
r.n. maini, p.c. taylor, j. szechinski, k. pavelka, j. bröll, g. balint, et al. double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in european patients with rheumatoid arthritis who had an incomplete response to methotrexate arthritis...
2023 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/).To maintain a healthy skeleton, vitamin D is crucial for phosphate as well as calcium uptake. It is of great significance ...
Gold nanoparticles have attracted enormous scientific and technological interest due to their ease of synthesis, chemical stability, and unique optical properties. Proof-of-concept studies demonstrate their biomedical applications in chemical sensing, biological imaging, drug delivery, and cancer treatment. ...
Historically, the classification of the CTCL subtype has been based on the presence or absence of specific cellular markers on malignant T cells. For example, more than ten years ago, Campbell et al. [4] discovered that MF cells typically have markers of skin tissue-resident effector memory T...
The current treatment strategy for RA demands a treat-to-target approach based on tight monitoring of disease activity and therapeutic adaptation when the treatment target is not achieved [6,7,8]. First-line therapy usually employs conventional synthetic DMARD as monotherapy (such as methotrexate, ...