Drugs that can cause macrovesicular steatosis and steatohepatitis include methotrexate, tamoxifen, and perhexiline. Methotrexate treatment can result in the development of steatosis, inflammation, hepatocyte ba
Aspirin and other NSAIDs also increase the toxicity of methotrexate and valproic acid and can decrease the effect of certain antihypertensive drugs (e.g., β-adrenoreceptor blockers, diuretics, and ACE inhibitors). However, long-term low doses of aspirin used for antiplatelet therapy appear not...
Expression of costimulatory molecules B7-1/B7-2 and Fas is increased on L1210 cells, but not L1210/DDP, in the presence of methotrexate or trimetrexate (TMTX). Therefore, a component of the mechanism of action of some anti-cancer agents may be to facilitate immune recognition and T cell...
methotrexate has been found to be helpful in treating certain diseases associated with abnormally rapid cell growth, such as cancer of the breast and psoriasis. Recently, methotrexate has been shown to be effective in inducing
Methotrexate analysis with quantitative UPLC-MS/MS for clinical researchForgo cross reactivity the selective detection of the ACQUITY UPLC I-Class PLUS/Xevo TQD for methotrexate analysis for clinical research. Mycophenolic acid analysis with quantitative UPLC-MS/MS for clinical researchAnalyze highly selec...
Methotrexate 1, Infliximab 1 Immunosuppression 18 Co–amoxiclav 4, Penicillin V 3, Amoxicillin 3, Flucloxacillin 2, Diarrhoea 7, Rash 4, Vomiting 4, Lip swelling 1, Deranged Cefaclor 1, Cefalexin 1, Cefotaxime 1, Teicoplanin 1, Erythromycin 1 LFTs 1, Thrush 1 Insulin detemir...
Methotrexate drug usage statistics for the United States (2013 - 2022). Statistics include drug synonyms and therapeutic classes, including: Methotrexate Sodium, Methotrexate, Jylamvo, Otrexup, Otrexup Pfs, Rasuvo, Reditrex, Abitrexate, Folex, Folex Pfs,
Pharmacokinetics of methotrexate (MTX) and 7-hydroxymethotrexate (7-OH-MTX) in rats and evidence for the metabolism of MTX to 7-OH-MTX. Cancer Chemother Pharmacol. 1989;23(3):156–60. Article CAS PubMed Google Scholar Slordal L, Jaeger R, Kjaeve J, Aarbakke J. Pharmacokinetics of 7...
[135]. Given that immune reactions contribute to uveitis pathogenesis, combined corticosteroid and immunosuppressive therapy (e.g., methotrexate) may be considered for recurrent cases [136,137]. Intermediate and panuveitis with vascular lesions and macular edema can be treated with intravitreal ...
Examples are drawn mainly from antibodies, given that the majority of available clinical data are from this class of protein therapeutics. Plausible and seemingly tractable solutions are in sight for some immunogenicity problems, whereas other challenges will likely require completely new approaches....