Fluoroquinolones are derivatives of quinolones and contain a 6-fluoro and 7-piperazine substituent. Despite structural variations, these compounds are collectively termed quinolones. The quinolones achieve their antimicrobial activity through inhibition of bacterial replication and transcription by blocking DNA ...
Liver fat storage, also called hepatic steatosis, is increasingly common and represents a very frequent diagnosis in the medical field. Excess fat is not without consequences. In fact, hepatic steatosis contributes to the progression toward liver fibrosis. There are two main types of fatty liver di...
Good's buffers are excellent and widely used in a variety of biological experiments, but there are still problems. For example, The piperazine-based species (PIPES and HEPES) have a rather rich redox chemistry. In particular, Tris buffer is widely used, but it is not a Good's buffer[4]...
The structures of both azoles contain extended piperazine-phenyl-triazole side-chains, but posaconazole is composed of a furan ring with fluorine substituted for chlorine. Like other compounds in the azole class, posaconazole disrupts fungal ergosterol biosynthesis through inhibition 14a-lanosterol ...
Be cautious using tablets and spot-ons containing ivermectin or ivermectin-related compounds (moxydectin, milbemycin, selamectin etc.) in collies; collie-crosses and Australian shepherd breeds. Some of these animals are highly sensitive to these drugs and can develop severe and bizarre neurological sig...
Moreover, in recent years, several new synthetic compounds have emerged. Many of these substances are marketed as 'legal highs' and substitutes for illicit stimulant drugs such as cocaine or 'ecstasy'. Two examples are piperazine and mephedrone, which are not under international control. A ...
). Thus, the notion that TTCC pharmacological blockers used in the cardiovascular or neurological fields could have a chemotherapeutic value was consolidated through in vitro studies, which showed that tetralol, 3,4-dihydroquinazoline, and diphenylpiperazine derivatives not only inhibited proliferation, ...
1- [2- (2, 4-DIMETHYLPHENYLSULFANYL) -PHENYL] PIPERAZINE AS A COMPOUND WITH COMBINED SEROTONIN REUPTAKE, 5-HT3 AND 5-HT1A ACTIVITY FOR THE TREATMENT OF COG... Said compounds is useful in the treatment of affect affective disorders; depression, major depressive disorder; postnatal depression; ...
CalixareneLiquid–liquid extractionComplexationChromiumMetalsThis article displays the synthesis of N -(2-tosylato)ethylpiperazine ( ii ) and 5,11,17,23-tetra- tert- butyl-25,27-bis-(2-piprazinoethyl)-26,28-dihydroxycalix[4]arene ( 3 ). Compounds ( ii) and 3 were characterized through ...