Mechanism of action Piperazine is a GABA receptor agonist. Piperzine binds directly and selectively to muscle membrane GABA receptors, presumably causing hyperpolarization of nerve endings, resulting in flaccid paralysis of the worm. While the worm is paralyzed, it is dislodged from the intestinal lume...
(1964c) Mechanism of the paralysing action of piperazine on Ascaris muscle. Br. J. Pharmac. 22: 463-477.DEL CAST1LLO, J., DE MELLO, W.C. & MORALES, T. (1964a). Mechanism of the paralysing action of piperazine on Ascaris muscle. Br. J. Pharmac., 22, 463-477....
2. del Castillo J, De Mello WC, Morales T (1964). Mechanism of the paralysing action of piperazine on Ascaris muscle. Br J Pharmacol, 22, 463–477. 3. Macmillan AL (1973). Generalized pustular drug rash. Dermatologia, 146, 285–291. ...
Mechanism of action Piperazine is a GABA receptor agonist. Piperzine binds directly and selectively to muscle membrane GABA receptors, presumably causing hyperpolarization of nerve endings, resulting in flaccid paralysis of the worm. While the worm is paralyzed, it is dislodged from the intestinal lume...
Diethylcarbamazine(36.1.2) (Fig. 36.1.) is a drug that has been used for many years to treatlymphatic filariasis, a significant public health problem across the developing world, in humans and animals; it also affects intestinal nematodes, but its mechanism of action remains unclear. Its mode...
The mechanism of action of 1-METHANESULFONYL-PIPERAZINE in pharmaceutical applications is not specified. Storage ConditionsStore in a cool and dry place. View all 4. Safety and Handling4.1 Safety Safety information of 1-(Methylsulphonyl)piperazine (55276-43-2): Hazard Codes Xi Risk Statements...
As such, they act by interfering with the life cycle of the hepati... ROBERT B. PERNI,SHAWN D. BRITT,JOHN H. VAN DRIE,... - CN 被引量: 172发表: 2005年 Mechanism of action of hypolipidemic and herbicidal aryloxy acids A mechanism of action of hypolipidemic and herbicidal aryloxy acids...
To better understand the mechanism of action of the best binding molecule 5, we carried out an analysis of the complexes over the 100 ns simulations within the binding pocket of HBsAg. For molecule 5, the interaction patterns show that the hydrogen bonds stay stable throughout the MD simulation...
The mechanism of action for the potent cytotoxicity of the ETPs has not been fully elucidated. However, several different activities have been described, including: generation of reactive oxygen species through oxidation of the polysulfide bridge,2 intracellular induction of the c-fos proto- oncogene...
The mechanism of action is still not clear, inhibition of phosphodiesterase with a resulting increase in intracellular cyclic AMP does occur, but not apparently at concentrations normally used for clinical effect. Other proposed mechanisms of action include adenosine receptor antagonism, prostaglandin ...