The article reports on the warning issued by the British Medicines and Healthcare products Regulatory Agency (MHRA) to vendors of BZP pills that contain benzylpiperazine (PEP). Manufacturers claim that BZP is a natural product that can provide a legal or herbal high. According to MHRA, BZP ...
“legal highs” under names such as “A2,”“Jet,”“Charge,”“Party Pills,” and “Legal X” and are used recreationally for their stimulant and entactogenic effects similar toamphetaminesandMDMA(Table 4displays names of commonly encounteredpiperazinesand some of the commercial products in ...
(1c, 2c). Commonly, piperazines are sold as party pills on the black market or over the Internet, and generally piperazine blends are consumed (3r). Several countries (USA, Australia, Japan, and countries in the European Union) regulatebenzylpiperazinederivatives under drug control legislation...
activity. The invention further relates to methods for their preparation and pharmaceutical compositions comprising them. The invention also relates to the use of said compounds for the manufacture of a medicament for the prevention or the treatment of a disease mediated by DGAT, in particular DGAT ...
According to the United Nations Office on Drugs and Crime, new psychoactive substances (NPS) are molecules designed and synthesized from small changes in the molecular structure of substances already known and controlled, such as ecstasy and cannabis, mimicking or enhancing their effects. Compounds wit...
The pharmaceutical composition can be formulated as solutions in pharmaceutically compatible solvents or as emulsions, suspensions or dispersions in suitable pharmaceutical solvents or vehicles, or as pills, tablets or capsules that contain solid vehicles in a way known in the art. ...
The present invention relates to melanocortin receptor agonists of formula I, which is useful in the treatment of obesity, diabetes and male and/or female sexual dysfunction <
Legal piper- azine-containing party pills--a new trend in substance misuse. Drug Alcohol Rev. 2007;26:335-343.Sheridan J., Butler R., Wilkins C., Russell B. Legal piperazine-containing party pills--a new trend in substance misuse. Drug Alcohol Rev 2007; 26: 335-43....
Generally, they are consumed as capsules, tablets or pills but also in powder or liquid forms. Currently, the precise mechanism by which piperazine designer drugs induce hepatotoxicity and whether they act by a common pathway is unclear. To answer this question, we performed a gene array study ...
'Piperazine-containing party pills' were marketed and sold as legal alternatives to methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA) until 2008 in New Zealand. The major constituents of these 'pills' were benzylphenylpiperazine (BZP) and trifluoromethylphenylpiperazine (TFMPP). Despite their...