[19]. Mori S, Kohyama M, Yasumizu Y, et al. Neoself-antigens are the primary target for autoreactive T cells in human lupus. Cell. 2024;187(21):6071-6087.e20. [20]. Dai D, Gu S, Han X, et al. The transcription factor...
B cells are specialized lymphocytes that play a central role in the humoral component of theadaptive immune response. Naïve B cells are produced from hematopoietic stem cells in the bone marrow and exhibit plasticity as part of the adaptive response with several distinct possible outcomes, includin...
Jun 05, 2024 - Mesenchymal stem cells (MSCs) are adult stem cells with the ability to differentiate into various types of mesoderm-derived cells, showing promising results in preclinical studies for various medical conditions. Research continues to explo
And I think that while bispecific antibodies have been great and they're highly efficacious, and many people do well, the unfortunate reality is only about half the patients we give them to are going to have a durable response. So we do need to be thinking about what comes next, because...
Cell surface proteins are of special interest for the understanding of how CHO cells react to their environment while maintaining growth and survival phenotypes, since they enable cellular reactions to external stimuli and potentially initiate signaling pathways. To provide deeper insight into functions ...
such as CD5, CD19, CD23, weak CD20 and immunoglobulin kappa/lambda, are used with consensus in routine diagnostics and are considered required in screening panels. Other markers are recommended as they can provide additional information to better characterize neoplastic B cells or are of prognostic...
known as B-cell aplasia. CD19 is also expressed on normal B cells, which are responsible for producing antibodies that kill pathogens. These normal B cells are also often killed by the infused CAR T cells. To compensate, many patients must re...
Several cellular products, e.g., CD19-directed Chimeric Antigen Receptor (CAR) T cells, are poised for FDA approval and thus increased use at a wider range of academic centers within the next year, with the likelihood of dissemination to standard oncology practice once safety is confirmed. ...
CD19-targeted chimeric antigen receptor-engineered (CAR)-T cells are novel therapies showing great promise for patients with relapsed or refractory diffuse large B cell lymphoma (DLBCL), primary mediastinal B cell lymphoma, mantle cell lymphoma, and follicular lymphoma. EMA-approved and commercially ...
A subcategory of bsABs, the bispecific T-cell engagers (BiTEs), target both tumor cells and immune cells; bridging tumor cells with T-cells leads to T-cell activation and tumor cell lysis. There are only 2 bsABs currently on the US market; however, Labrijn et al. reported more than ...