[19]. Mori S, Kohyama M, Yasumizu Y, et al. Neoself-antigens are the primary target for autoreactive T cells in human lupus. Cell. 2024;187(21):6071-6087.e20. [20]. Dai D, Gu S, Han X, et al. The transcription factor...
B cells are specialized lymphocytes that play a central role in the humoral component of theadaptive immune response. Naïve B cells are produced from hematopoietic stem cells in the bone marrow and exhibit plasticity as part of the adaptive response with several distinct possible outcomes, includin...
Sample cells are passed through a narrow channel one at a time. Light is used to illuminate the cells in the channel. A series of sensors detect the types of light that are refracted or emitted from the cells. Data acquired by the sensors is compiled and integrated to build a comprehensive...
Jun 05, 2024 - Mesenchymal stem cells (MSCs) are adult stem cells with the ability to differentiate into various types of mesoderm-derived cells, showing promising results in preclinical studies for various medical conditions. Research continues to explo
And I think that while bispecific antibodies have been great and they're highly efficacious, and many people do well, the unfortunate reality is only about half the patients we give them to are going to have a durable response. So we do need to be thinking about what comes next, because...
B cells are lymphocytes produced and differentiated in the bone marrow. When they come in contact with an antigen, usually an extracellular one, they turn into effector cells, called plasma cells, that secrete antibodies. In addition to their function in ...
Cell surface proteins are of special interest for the understanding of how CHO cells react to their environment while maintaining growth and survival phenotypes, since they enable cellular reactions to external stimuli and potentially initiate signaling pathways. To provide deeper insight into functions ...
Efforts to determine an effective vaccine that alerts the immune system to cancer cells have largely failed; however, experimental cancer vaccines containing proteins that are overexpressed by tumour cells may work synergistically with other immunotherapies [16, 17]. Talimogene laherparepvec (T-VEC) ...
Several cellular products, e.g., CD19-directed Chimeric Antigen Receptor (CAR) T cells, are poised for FDA approval and thus increased use at a wider range of academic centers within the next year, with the likelihood of dissemination to standard oncology practice once safety is confirmed. ...
Efforts to determine an effective vaccine that alerts the immune system to cancer cells have largely failed; however, experimental cancer vaccines containing proteins that are overexpressed by tumour cells may work synergistically with other immunotherapies [16, 17]. Talimogene laherparepvec (T-VEC) ...