Warburg effectSPC25 is associated with unfavorable outcomes in various cancers, but its role in prostate cancer (PRAD) is unclear. More research is needed on glycolysis and ferroptosis targets in PRAD. Bioinformatics tools were used to analyze SPC25 expression disparities. Gene set enrichment ...
the degradation of this protein (Kamemura et al., 2002). In prostate cancer cells, inhibition of OGT lead to decreased c-Myc protein abundance, while its mRNA level was unchanged. This finding indicates a stabilizing effect of O-GlcNAc on c-Myc protein (Itkonen et al., 2013) (Fig. 2)...
In most aggressive cancer types, the tumor microenvironment exhibits a reciprocal pro-tumorigenic metabolic phenotype consistent with the reverse Warburg effect (RWE). The RWE can be viewed as a physiologic response to the epithelial phenotype that is independent of both the epithelial genotype and of...
Cancer cells show a broad spectrum of bioenergetic states, with some cells using aerobic glycolysis while others rely on oxidative phosphorylation as their main source of energy. In addition, there is mounting evidence that metabolic coupling occurs in a
Understanding the Warburg effect and the prognostic value of stromal caveolin-1 as a marker of a lethal tumor microenvironment Federica Sotgia, Ubaldo E Martinez-Outschoorn, Stephanos Pavlides, Anthony Howell, Richard G Pestell & Michael P Lisanti Breast Cancer Research volume 13, Article...
Hypoxia signaling plays a major role in non-malignant and malignant hyperproliferative diseases. Pulmonary hypertension (PH), a hypoxia-driven vascular disease, is characterized by a glycolytic switch similar to the Warburg effect in cancer. Ras associat
Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer-related death worldwide. Countless CRC patients undergo disease progression. As a hallmark of cancer, Warburg effect promotes cancer metastasis and remodels the tumor microenvironment, including promoting ang...
During hepatocellular carcinoma progression, E2F1 promoted the expression of its genes involved in glycolysis, which contributed to the Warburg effect [44]. In bladder and prostate cancer cell lines, E2F1 enhanced cancer cell glycolysis by directly binding to the proximal SIRT6 promoter and suppressed...
named after the discoverer, the Warburg effect [8], and the last 10 years have seen a renewed interest and increasingly vigorous research into cancer cell metabolism. The aim was not only to understand the basics governing the Warburg effect, but also to comprehend the purpose of such a metab...
“Warburg effect”) is a common feature of cancer cells. In this study, we develop a lactate-responsive drug delivery platform by targeting the Warburg effect. We design and test a gold/mesoporous silica Janus nanoparticle system as a gated drug carrier, in which the gold particles are ...