To be, or not to be?" This question is not only Hamlet's agony but also the dilemma of mitochondria in a cancer cell. Cancer cells have a high glycolysis rate even in the presence of oxygen. This feature of cancer cells is known as the Warburg effect, named for the first scientist ...
近日,叶江滨实验室在Cancer Research上发表了题为Mitochondrial uncoupling induces epigenome remodeling and promotes differentiation in neuroblastoma的文章,发现线粒体解偶联剂可促进肿瘤表观遗传组重构和诱导肿瘤分化。 百年以前,德国生理学家、诺...
近日,叶江滨实验室在Cancer Research上发表了题为Mitochondrial uncoupling induces epigenome remodeling and promotes differentiation in neuroblastoma的文章,发现线粒体解偶联剂可促进肿瘤表观遗传组重构和诱导肿瘤分化。 百年以前,德国生理学家、诺贝尔奖得主奥托.H.瓦博格 (Otto H. Warburg) 发现并以他的名字命名...
百度试题 结果1 题目什么是warburg effect 相关知识点: 试题来源: 解析 瓦博格效应Warburg effect is that cancer cells exhibit an increased dependence on glycolytic pathway for ATP generation.“瓦博格效应”即指肿瘤细胞对糖酵解通路产能依赖增强的现象.反馈 收藏 ...
参考文献【1】Understanding the Warburg effect: the metabolic requirements of cell proliferation,DOI:10.1126/science.1160809【2】Saturation of the mitochondrial NADH shuttles drives aerobic glycolysis in proliferating cells,DOI:10.1016/j.molcel.2022.07.007【3】Cell-programmed nutrient partitioning in the tum...
Most cancer cells employ the Warburg effect to support anabolic growth and tumorigenesis. Here, we discovered a key link between Warburg effect and aberrantly activated Wnt/β-catenin signalling, especially by pathologically significant APC loss, in CRC.
Cancer cells employ both conventional oxidative metabolism and glycolytic anaerobic metabolism. However, their proliferation is marked by a shift towards increasing glycolytic metabolism even in the presence of O2 (Warburg effect). HIF1, a major hypoxia induced transcription factor, promotes a dissociation...
Gogvadze V, Zhivotovsky B, Orrenius S (2010) The Warburg effect and mitochondrial stability in cancer cells.Mol. Aspects Med.31(1), 60–74. Lunt SY, Vander Heiden MG (2011) Aerobic glycolysis: meeting the metabolic requirements of cell proliferation.Annu. Rev. Cell Dev. Biol.27, 441...
Results and Discussion Cancer cells exhibit dual metabolic nature – Warburg effect versus a nonglycolytic phenotype. Under regular culture conditions, cancer cells showed a typical Warburg effect, converting most incoming glucose to lactate; however, under lactic acidosis, they became less glycolytic ...
cells, c-MYC is inhibited by HIF-1, but in cancer cells it interacts with HIF-1, further enhancing the Warburg effect by increasing the expression of glycolytic enzymes [28]. However, the most notable mechanism is the stimulation of the Warburg effect by mTOR/HIF-1/MYC through the up...