Warburg effect advantage for cancer cells—biomass and NADPH production. The main metabolic pathways contributing to biomass production in a cancer cell as nucleotide synthesis, the pentose phosphate pathway, serine synthesis, glutaminolysis, cholesterol synthesis, and fatty-acid synthesis are presented. In...
Summarized in a few words, the prime cause of cancer is the replacement of the respiration of oxygen in normal body cells by a fermentation of sugar.’ This review illuminates the pivotal role of the Warburg effect in tumorigenesis, particularly the profound impact of the Warburg effect on ...
Warburg Effect or Reverse Warburg Effect? A Review of Cancer Metabolismdoi:10.1159/000375435Cancer is a major threat to human health. A considerable amount of research has focused on elucidating the nature of cancer from its pathogenesis to treatment and prevention. Tumor cell metabolism has been ...
Warburg effect or reverse Warburg effect? A review of cancer metabolism. Cancer is a major threat to human health. A considerable amount of research has focused on elucidating the nature of cancer from its pathogenesis to treatm... Xiao,Dong,Xu,... - 《Oncology Research & Treatment》 被引...
The Warburg effect is the reverse of the Pasteur effect (the inhibition of fermentation by O2) exhibited by cancer cells; alteration of the Pasteur effect in cancer is linked to prolyl hydroxylases and hypoxia-inducible factor (HIF). Tumour suppressors and oncogenes converge on HIF to reverse ...
Cell Communication and Signaling (2023) 21:100 https://doi.org/10.1186/s12964-022-01025-9 Cell Communication and Signaling REVIEW Open Access The Warburg effect modulates DHODH role in ferroptosis: a review Alvan Amos1,2, Alex Amos3, Lirong Wu1 and He Xia1* Abstract ...
Despite the effect of deuterium enrichment, research efforts have largely focused on developing carbonyl-bearing molecules as molecular imaging probes. The focus of this review is to introduce representative compounds relevant to metabolism that are characteristic of cancer tissue and have been applied in...
Warburg effect, which will be discussed in this review. Dichloroacetate and 3-bromopyruvate are among the substances that have been studied as potential cancer therapies. With our expanding knowledge of cellular metabolism, therapies targeting the Warburg effect appear very promising. This review ...
Targeting Warburg metabolism would be a promising method for the treatment of CRC. In this review, we summarize information about the roles of Warburg effect in tumor microenvironment to elucidate the mechanisms governing Warburg effect in CRC and to identify novel targets for therapy....
Nature Reviews Cancer (2016). Pavlides, S. et al. The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma. Cell Cycle 8, 3984–4001 (2009). Article CAS PubMed Google Scholar Pietras, K. & Östman, A. Hallmarks of cancer: interactions with ...