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Molecular Genetic Insights Into Varicella Zoster Virus (VZV), the vOka Vaccine Strain, and the Pathogenesis of Latency and Reactivation. PMID: 30247591 Targeted Genome Sequencing Reveals Varicella-Zoster Virus Open Reading Frame 12 Deletion. PMID: 28747504 Antiviral Targeting of Varicella Zoster Virus Re...
This virus has been modified by the introduction into its genome of heterologous DNA which encodes an immunogenic polypeptide of another human pathogen. This heterologous polypeptide is expressed in cells infected by the recombinant virus. Such recombinant VZV is useful as a vaccine for chickenpox as...
The varicella zoster virus is a DNA virus with a genome that encodes 70 proteins. The Tzanck preparation shows characteristic findings of giant cells with 2-15 nuclei. Recently infected epithelial cells contain a single enlarged nucleus with a thick nuclear membrane. ...
Genome-wide mutagenesis reveals that ORF7 is a novel VZV skin-tropic factor. PMID: 20617166 Varicella-zoster virus: molecular virology and virus-host interactions. PMID: 11495809 Development of recombinant varicella-zoster virus vaccines. PMID: 10599531 ...
FIG. 1. Construction of recombinant VZV with an epitope or stop codons inserted into ORF1. The prototype VZV genome is 124,884 bp in length (line 1) and contains unique long (UL), unique short (Us), terminal repeat (TR), and internal repeat (IR} DNA sequences (line 2). The Notl...
The VZV virion contains an icosahedralnucleocapsid surrounding a core that contains the linear, double-stranded DNA genome as well as a protein tegument that separates the capsid from the lipid envelope. This envelope incorporates all of the major viral glycoproteins. The VZV nucleocapsid protein, ...
Introduction VZV is closely related to the herpes simplex viruses(HSV), sharing much genomehomology. The known envelope glycoproteins (gB, gC, gE, gH, gI, gK, gL) correspond with those in HSV, however there is no equivalent of HSV gD. VZV virons are spherical and 150-200 nm in diameter...
PMID: 23170169 Genome-wide mutagenesis reveals that ORF7 is a novel VZV skin-tropic factor. PMID: 20617166 Varicella-zoster virus: molecular virology and virus-host interactions. PMID: 11495809 Development of recombinant varicella-zoster virus vaccines. PMID: 10599531 Genotypes of clinical varicella-...