Vertex Advances VX-548 in Acute and Neuropathic Pain July 22, 2022 - VX-548 advances into pivotal development for people with acute pain; Phase 3 program to initiate in Q4 2022 - - Phase 2 dose-ranging trial in neuropathic pain expected to initiate by year end - -Breakthrough Therapy ...
VX-548 has been granted Breakthrough Therapy and Fast Track designations in the U.S. for moderate to severe acute pain. In addition, Vertex has initiated a Phase 2 dose-ranging study of VX-548 in neuropathic pain. About VX-548 VX-548 is an oral, selective NaV1.8 inhibitor that is ...
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Oncol. 9, 542–548 (2012). 3. Garraway, L. A. Genomics-driven oncology: framework for an emerging paradigm. J. Clin. Oncol. 31, 1806–1814 (2013). 4. Larsen, J. E., Cascone, T., Gerber, D. E., Heymach, J. V. & Minna, J. D. Targeted therapies for lung cancer: ...