IntroductionIt has been recognized that significant transporter interactions result in volume of distribution changes in addition to potential changes in clearance. For drugs that are not clinically significant transporter substrates, it is expected that drug–drug interactions would not result in any ...
3.分布体积(volume of distribution): 3.4 ± 0.9 L 。4. 血浆浓度:600±17mg/ml禁忌: 已知对此药物成物质过敏者,请勿注射。 www.p53.cn|基于47个网页 3. 分布容积 ... 分布曲线 profile curve分布容积volume of distribution分布无关性/免分布 distribution free ... ...
Eq. (1)represents the Vdof the central compartment as the dose takendivided by the plasma concentration of the drug at time zero(C0) (Shargel and Yu, 1999).Vd=DoseC0(1)Two different terms have been used to describe the vol-ume of distribution for drugs that follow multiple exponential...
The data set consisted of the volume of distribution of 129 pharmacologically important compounds, i.e., benzodiazepines, barbiturates, nonsteroidal anti-inflammatory drugs (NSAIDs), tricyclic anti-depressants and some antibiotics, such as betalactams, tetracyclines and quinolones. The descriptors, ...
Mahmood I: Prediction of clearance and volume of distribution in the obese from normal weight subjects: an allometric approach. Clin Pharmacokinet 2012; 51... Mahmood,Iftekhar - 《Clinical Pharmacokinetics》 被引量: 15发表: 2012年 Effect of Obesity on the Pharmacokinetics of Drugs in Humans adjus...
The current study was conducted to investigate QSPR for apparent volume of distribution (V d ) in man among 24 Quinolone drugs employing an extrathermodynamic approach. It is vital to predict the V d value of various drug leads during drug discovery so that compounds with poor bioavailability ...
网络释义 1. 表观分布容积 药剂词汇英汉对照 ... Antioxidant 抗氧化剂Apparent volume of distribution表观分布容积Rate constant 速度,速率 ... www.360doc.com|基于100个网页 2. 表观内在容积 中国药科大学2011药理复试题+药理题库 ... ... mitotic poison( 有丝分裂毒物)apparent volume of distribution(表...
The aim of this study was to develop a regression equation for predicting volume of distribution at steady state (Vdss) in humans to enable application to various types of drugs using animal experimental data for rats and dogs and some molecular structural parameters. The Vdss data for rats, do...
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Biocompatibility, Surface Engineering, and Delivery of Drugs, Genes and Other Molecules M.Colilla,M.Vallet-Regí, inComprehensive Biomaterials, 2011 4.429.4.1.3Pore volume The adsorption of molecules intoSMMsis a molecule-surface interaction, and consequently, the amount of molecule loaded depends on ...