In vivo, Na+ channel α-subunits are associated with one or more accessory β-subunits (β1-β4) that regulate cell-surface expression, trafficking, and gating properties of the channels. Depending on the physical properties of the drug, Na+ channel inhibition can occur by a simple pore-...
Voltage-gated Na channels are responsible for the Na current that underlies the rapid upstroke of the action potential in nerve and muscle fibres. Mutations in sodium channel genes may therefore be expected to result in diseases of nerve and muscle, including cardiac muscle. In the mutations...
Voltage-gated Na+ (NaV) channels are key mediators of neuronal function and essential for neuronal excitability. Their abnormal activity is implicated in the generation of seizures, both in acquired and genetic epilepsy. Several of the most widely used antiepileptic drugs inhibit NaV activity by ...
The subtype composition, density and distribution of voltage-gated Na+ channels determine the property of the various types of neurons or the specific areas of each neuron26. Also, expression and distribution of the different members of the voltage-gated Na+channel family at the subcellular...
Na+channelscharacteristicstransductionDepolarizingThe mammalian utricular sensory receptors are commonly believed to be non-spiking cells with electrical activity limited to graded membrane potential changes. Here we provide evidence that during the first post-natal week, the sensory hair cells of the rat ...
Translation of this secretion to AP spiking levels is determined by the excitability of the afferent nerve terminals that is largely determined by the voltage-dependence of activation of Na+ channels. In this review, we examine the biophysical characteristics of Na+ channels present at the soma of...
A voltage-gated Na+ current was characterised in freshly dissociated mouse portal vein (PV) smooth muscle myocytes. The current was found superimposed upon... Sohag,Saleh,Shuk,... - 《Journal of Physiology》 被引量: 148发表: 2005年 Structure and function of voltage-gated sodium channels at ...
Channel proteins (such as the voltage-gated Na channel) transport ions much faster than carrier proteins (such as the Na-K pump), but they cannot be coupled to an energy source; therefore, transport mediated by channels is always passive. A.正确B.错误 相关知识点: 试题来源: 解析 A 反...
Voltage-sensing domains control the activation of voltage-gated ion channels, with a few exceptions1. One such exception is the sperm-specific Na+/H+ exchanger SLC9C1, which is the only known transporter to be regulated by voltage-sensing domains2–5. Af
Na+ Channel Activity in C×43-Defident Myocytes. Introduction: Dynamic interplay between active and passive electrical properties of cardiac myocytes is based on interrelationships between various channels responsible for depolarizing and repolarizing ionic currents and intercellular conductances. Mice with ...