Interestingly, there does not appear to be a strict correlation between functional KV2.1 channel blocking activity and the ability to displace 125I-GxTX-1E binding to KV2.1 channels. This lack of correlation is quite clear in the representative titrations shown in Figure 6. Compound A and ...
Mutation p.V1184A enhances the activity of NaV1.9 channels by shifting the voltage-dependence of channel activation to more hyperpolarized voltages and by reducing the voltage-dependence of channel inactivation. Colored areas indicate voltage ranges of basal channel activity (window current) generated ...
Atomic structure of a voltage-dependent K þ channel in a lipid membrane-like environment. Nature 450, 376–382 (2007). 4. Jan, L. Y. & Jan, Y. N. Voltage-gated potassium channels and the diversity of electrical signalling. J. Physiol. 590, 2591–2599 (2012). 5. Nerbonne, J. ...
Acid addition salts (mono- or di-salts) may be formed with a wide variety of acids, both inorganic and organic. Examples of acid addition salts include mono- or di-salts formed with an acid selected from the group consisting of acetic, 2,2-dichloroacetic, adipic, alginic, ascorbic (e.g...
mono-aminergic uptake inhibitors such as venlafaxine; opioid analgesics; local anaesthetics; 5HT1 agonists, such as triptans, for example sumatriptan, naratriptan, zolmitriptan, eletriptan, frovatriptan, almotriptan or rizatriptan; nicotinic acetyl choline (nACh) receptor modulators; glutamate receptor...