We thus used a small molecule modulator of PIEZO1 activity, Yoda1, to promote conformational states of the PIEZO1 that may enter a voltage-gated mode. Yoda1 has been described as an opener of PIEZO1 channels in artificial lipid bilayers, but fails to directly gate the channel in whole-...
Single-pass transmembrane auxiliary subunits modulate other voltage-gated ion channel α subunits by a variety of mechanisms (32,38,40,41). However, AMIGO1 only shares a limited degree of homology with other single-pass transmembrane auxiliary subunits (42), and divergent structural interactions ...
In voltage-gated sodium (NaV) channels, each of the four paddle motifs has a unique sequence and can impart distinct functional and pharmacological properties.41 In contrast, in a homomeric KV channel, the four voltage sensors are equivalent and thus provide four identical binding sites. We ...
Conductance hysteresis in the voltage-dependent anion channel. Eur. Biophys. J. 2015, 44, 465–472. [CrossRef] [PubMed] 33. Bezanilla, F. Voltage-gated ion channels. IEEE Trans. NanoBiosci. 2005, 4, 34–48. [CrossRef] [PubMed] 34. Tao, X.; Lee, A.; Limapichat, W.; ...