Lu. 2013. Tuning volt- age-gated channel activity and cellular excitability with a sphin- gomyelinase. J. Gen. Physiol. 142:367-380. http://dx.doi.org/ 10.1085/jgp.201310986D.J. Combs, H.G. Shin, Y. Xu, Y. Ramu, Z. Lu, Tuning voltage-gated channel activity and cellular ...
K(+)-channel activity-mediated alteration of the membrane potential and cytoplasmic free Ca2+ concentration ([Ca2+]cyt) is a pivotal mechanism in controlli... XJ Yuan,W Jian,M Juhaszova,... - 《Am J Physiol》 被引量: 429发表: 1998年 Functional subunit structure of voltage-gated calcium ...
This regulates ion selective fluxes on the microsecond–millisecond timescale. They are crucially involved in regulating activity in excitable cells of the CNS and in skeletal muscle fibres. VGICs are directly involved in control of cellular resting potential, neurotransmitter release, determination of ...
Both voltage-gated and ligand-gated ion channels are large protein molecules, as is the sodium pump Na,K-ATPase. In recent years the primary structure of a number of them has been determined, and by combining this information with the biophysical evidence, major advances have been made in our...
The Two Nucleotide-binding Domains of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Have Distinct Functions in Controlling Channel Activity The cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel contains two cytoplasmic nucleotide-binding domains (NBDs). After phosphorylatio.....
Voltage-gated ion channels are targeted to precise locations in polarized neurons that affect the response of the neuron to electrical activity. Neurons can adjust channel activities by modifying channel properties or altering channel densities. In general, voltage-gated sodium (Nav) and voltage-gated...
5 The Development of Voltage-Gated Ion Channels and Its Relation to Activity-Dependent Developmental Events Spontaneous activity is an essential feature in the development of the nervous system. The patterns of activity and the waveform and ionic dependence of the action potentials that occur during ...
channel5), BeKm1 (hERG channel6) or µ-conotoxin KIIIA (NaV1.27) are selective for a particular target. Others bind to virtually an entire class of ion channels (i.e. AaHII and NaVchannels8). Hence, venom peptides appear as a promising class of compounds to control the activity of...
Voltage-gated ion channels regulate many physiological functions and are targets for a number of drugs. Patch-clamp electrophysiology is the standard method for measuring channel activity because it fulfils the requirements for voltage control, repetitive stimulation and high temporal resolution, but it ...
The invention concerns the genomic DNA, cDNA, and polypeptide sequences of CanIon, a novel voltage gated ion channel protein. The invention also concerns biallelic markers of the Ca