Combs DJ, Shin HG, Xu Y, Ramu Y, Lu Z (2013) Tuning voltage- gated channel activity and cellular excitability with a sphin- gomyelinase. J Gen Physiol 142:367-380Combs DJ, Shin HG, Xu Y, Ramu Y, Lu Z (2013) Tuning voltage-gated channel activity and cellular excitability with a ...
Electrical signaling by ion channels is a fundamental cellular regulatory pathway in all organisms from prokaryotes to humans. Voltage-gated Na+(VGSC), Ca2+(VGCC), and K+(VGPC) channels are responsible for action potential generation in electrically excitable cells, for example, neurons and muscle...
Voltage-gated ion channels generate electrical activity in excitable cells. As such, they are essential components of neuromuscular and neuronal systems, a... SM Messerli,RM Greenberg - 《Marine Drugs》 被引量: 39发表: 2006年 Calcium-activated SK channels influence voltage-gated ion channels to ...
This regulates ion selective fluxes on the microsecond–millisecond timescale. They are crucially involved in regulating activity in excitable cells of the CNS and in skeletal muscle fibres. VGICs are directly involved in control of cellular resting potential, neurotransmitter release, determination of ...
Voltage-gated ion channels are targeted to precise locations in polarized neurons that affect the response of the neuron to electrical activity. Neurons can adjust channel activities by modifying channel properties or altering channel densities. In general, voltage-gated sodium (Nav) and voltage-gated...
The invention concerns the genomic DNA, cDNA, and polypeptide sequences of CanIon, a novel voltage gated ion channel protein. The invention also concerns biallelic markers of the Ca
Changes in voltage-gated Na+ channel activity can play a role in reorganization, recovery, or possibly excitotoxic damage following injury. Prolonged hypoxemia in fetal llama brain caused a significant decrease in the expression of NaV1.1 and less so for NaV1.2 channels detected with Anti-...
channel5), BeKm1 (hERG channel6) or µ-conotoxin KIIIA (NaV1.27) are selective for a particular target. Others bind to virtually an entire class of ion channels (i.e. AaHII and NaVchannels8). Hence, venom peptides appear as a promising class of compounds to control the activity of...
Voltage-gated ion channels are targeted to precise locations in polarized neurons that affect the response of the neuron to electrical activity. Neurons can adjust channel activities by modifying channel properties or altering channel densities. In general, voltage-gated sodium (Nav) and voltage-gated...
Abstract Neuropathic pain (NP) is a chronic pain caused by injury or disease of the somatosensory nervous system, or it can be directly caused by disease. It often presents with clinical features like spontaneous pain, hyperalgesia, and dysesthesia. At present, voltage-gated calcium ion channels...