In skeletal muscle cells, the activity of the ClC-1 channel ensures the electrical stability of the excitable membrane. The widely expressed ClC-2 channel is activated by unphysiologically strong hyperpolarization and by extracellular hypotonicity. The physiological role of this channel is to ...
Presents a study that examined the expression and functional activity of endogenous voltage-gated chloride (Cl) channels in glioma cells. Methods used in proving the importance of voltage-gated chloride channels for cell proliferation; Attempts made to demonstrate and analyze the expression of ClC-2,...
Channel expression and voltage dependence of activation Having a structural organization similar to animal Hvs is not sufficient to predict proton channel activity, as previously shown with HVRP1/TMEM266, a membrane protein closely related to human Hv1 that does not function as a channel39,40,41...
Electrical signaling by ion channels is a fundamental cellular regulatory pathway in all organisms from prokaryotes to humans. Voltage-gated Na+(VGSC), Ca2+(VGCC), and K+(VGPC) channels are responsible for action potential generation in electrically excitable cells, for example, neurons and muscle...
Channel expression and voltage dependence of activation. Having a structural organization similar to animal Hvs is not sufficient to predict proton channel activity, as previously shown with HVRP1/TMEM266, a membrane protein closely related to human Hv1 that does not function as a channel39–41....
Voltage-gated ion channels are targeted to precise locations in polarized neurons that affect the response of the neuron to electrical activity. Neurons can adjust channel activities by modifying channel properties or altering channel densities. In general, voltage-gated sodium (Nav) and voltage-gated...
Voltage-gated potassium channel Potassium channel KvAP, structure in a membrane-like environment. Calculated hydrocarbon boundaries of the lipid bilayer are
The postnatal mammalian ovary undergoes a series of changes to ensure the maturation of sufficient follicles to support ovulation and fecundation over the reproductive life. It is well known that intracellular [Ca2+]i signals are necessary for ovulation,
Voltage-gated ion channels are targeted to precise locations in polarized neurons that affect the response of the neuron to electrical activity. Neurons can adjust channel activities by modifying channel properties or altering channel densities. In general, voltage-gated sodium (Nav) and voltage-gated...
Activity-dependent disinhibition II: Effects of extracellular potassium, furosemide, and membrane potential on ECl in hippocampal CA3 neurons. J. Neurophysiol. 61, 512–523 (1989). Article CAS Google Scholar Misgeld, U., Deisz, R.A., Dodt, H.U. & Lux, H.D. The role of chloride ...