voltage-gated sodium channelsblockersNav channel structureschannelopathiesVoltage-gated sodium(Nav)channels are critical players in the generation and propagation of action potentials by triggering membrane depolarization.Mutations in Nav channels are associated with a variety of channelopathies,which makes ...
Excitable cells — including neurons, muscle cells and cardiac myocytes — are unique in expressing high densities of voltage-gated sodium (NaV) channels. This molecular adaptation enables these cells to produce action potentials, and is essential to the
Storage: Store at -20°C The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. Tocris products are intended for laboratory research use only, unless stated otherwise. Product Datasheets ...
A selective NaV1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats. McGaraughty et al. J.Pharmacol.Exp.Ther., 2008;324:1204 Discovery and biological evaluation of 5-Aryl-2-furfuramides, ...
Voltage-gated sodium channel blockers as immunomodulators. Voltage-gated sodium channel blockers as immunomodulators. Recent Patents CNS Drug Discov. 1: 83-91.Roselli F,Livrea P,Jirillo E. Voltage-gated ... Francesco,Roselli,Paolo,... - 《Recent Patents on Cns Drug Discovery》 被引量: ...
Sodium channel blockers in neuropathic pain Importance of the field: The voltage-gated sodium channels (VGSCs) play a fundamental role in controlling cellular excitability and their abnormal activity... Valentina Zuliani,Mirko Rivara,Marco Fantini,... - 《Expert Opinion on Therapeutic Patents》 被引...
VOLTAGE-GATED SODIUM CHANNEL BLOCKERS 专利内容由知识产权出版社提供 专利名称:VOLTAGE-GATED SODIUM CHANNEL BLOCKERS 发明人:BOEHM, JEFFREY, CHARLES,DAVIS, RODERICK, S.,KERNS, JEFFREY,LIN, GUOLIANG,MURDOCH, ROBERT, D.,NIE, HONG 申请号:EP12806889 申请日:20120703 公开号:EP 272914 9A4 公开日:...
Voltage-gated Sodium Channels: Structure and FunctionSodium Channel Blockers in Clinical Use BenzocaineBupivacaineEtidocaineLevobupivacaineLidocaine (Lignocaine)MepivacainePrilocaineProcaineRopivacaineTetracaineAnticonvulsant Drugs CarbamazepineLamotrigineOxcarbazepinePhenytoinAntiarrhythmic Drugs MexilitineSodium channel ...
A-887826 is a structurally novel, potent and voltage-dependent NaV1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats. Zhang et al. Neuropharmacology, 2010;59:201 Product Datasheets COA view current batch SDS Reconstitution Calculator ...
Voltage-gated sodium channels are encoded by a family of ten structurally-related genes that are expressed in spatially and temporally distinct patterns, mainly in excitable tissues. They underlie electrical signalling in nerve and muscle. It has long been known that sodium channel blockers are anaes...