Voltage-gated Na channels are responsible for the Na current that underlies the rapid upstroke of the action potential in nerve and muscle fibres. Mutations in sodium channel genes may therefore be expected to result in diseases of nerve and muscle, including cardiac muscle. In the mutations...
The basis of epilepsy is an increase in neuronal excitability that, in some cases, may be caused by functional defects in neuronal voltage gated sodium channels, Nav1.1 and Nav1.2. The effects of antiepileptic drugs (AEDs) as effective therapies for epilepsy have been characterized by extensive ...
Voltage-gated Na+ Channel Characteristics The voltage-gated Na+ channels are composed of α-subunits that encode for the voltage sensor domains and the Na+-selective permeation pore. In vivo, Na+ channel α-subunits are associated with one or more accessory β-subunits (β1-β4) that regulate...
Voltage-gated Na+ (NaV) channels are key mediators of neuronal function and essential for neuronal excitability. Their abnormal activity is implicated in the generation of seizures, both in acquired and genetic epilepsy. Several of the most widely used antiepileptic drugs inhibit NaV activity by ...
Voltage-gated sodium channels (NaV) are responsible for the rapid depolarization of many excitable cells. They readily inactivate, a process where currents diminish after milliseconds of channel opening. They are also targets for a multitude of disease-c
Also, expression and distribution of the different members of the voltage-gated Na+channel family at the subcellular level, differs during the development19. The expression of voltage-gated Na+ channels is a dynamic process, and alterations in the physiological state as well as injury induc...
Fast opening and closing of voltage-gated sodium channels are crucial for proper propagation of the action potential through excitable tissues. Unlike potassium channels, sodium channel α-subunits are believed to form functional monomers. Yet, an increa
Voltage-gated Na+ channels (VGSCs) are macromolecular protein complexes containing a pore-forming α subunit and smaller non-pore-forming β subunits. VGSC... Brackenbury,J William - 《Channels》 被引量: 145发表: 2012年 Slow inactivation in voltage-gated sodium channels Slow inactivation in volt...
Voltage-gated Na+channels play a fundamental role in the excitability of nerve and muscle cells. Na+channels both open and close more quickly than potassium (K+) channels, producing an influx of positive charge (Na+) toward the beginning of the action potential and an efflux (K+) toward ...
电压-门控Na+通道 1. Thevoltage-gated sodium channelshave a close relationship with epilepsy,and many epileptic syndromes are proved to be caused by mutations ofvoltage-gated sodium channels. 电压-门控Na+通道和癫痫的关系十分密切,许多癫痫综合征的发生已被证明是由Na+通道基因突变引起,且编码α和/或...