doi:10.1016/j.bpj.2012.11.1565Delemotte, LucieKasimova, MarinaTarek, MounirTreptow, WernerCarnevale, VincenzoKlein, Michael L.Elsevier Inc.Biophysical Journal
The cloned α1 subunit exhibits structural features common to voltage-gated cation channel gene families and is capable of directing expression of calcium channel activity in heterologous expression systems. In the central nervous system (CNS), VGCCs are expressed by five distinct a1 subunit genes (...
Xu H,Ramsey IS,Kotecha SA et al.TRPV3 is a calcium-permeable temperature-sensitive cation channel.Nature. 2002Xu, H., Ramsey, I.S., Kotecha, S.A., Moran, M.M., Chong, J.A., Lawson, D., Ge, P., Lilly, J., Silos-Santiago, I., Xie, Y., et al. (2002). TRPV3 is a...
et al. Interaction of the pacemaker channel HCN1 with filamin A. J. Biol. Chem. 279, 43847–43853 (2004). Article CAS PubMed Google Scholar Kimura, K., Kitano, J., Nakajima, Y. & Nakanishi, S. Hyperpolarization-activated, cyclic nucleotide-gated HCN2 cation channel forms a protein ...
The action potential is an 'all or none' cellular response that is highly dependent upon a range of VGICs which are transiently permeable to Na + (cation influx depolarises the cell), K + (efflux for rapid repolarisation and refractoriness) and perhaps to a lesser extent Ca 2+ ions (...
Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and A... Neuronal members of the degenerin/epithelial Na(+) channel (DEG/ENaC) family of cation channels include the mammalian brain Na(+...
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca2+ release channels IR , Field LM , Wallace BA , Williamson MS , Davies TG ( 2015 ) An evolutionarily-unique heterodimeric voltage-gated cation channel found in aphids ... A Galione,AM Evans,J Ma,....
KCa channels have internal regulator of K+conductance (RCK) domains at their C terminus. These domains bind a broad range of biological ligands, including calcium, sodium, and nucleotides, that modulate channel activity (Giraldez and Rothberg, 2017). CNG, HCN, and voltage-gated KCNH...
Four-domain voltage-gated cation channels (FVCCs) represent a large family of pseudo-tetrameric ion channels which includes voltage-gated calcium (Cav) and sodium (Nav) channels, as well as their homologues. These transmembrane proteins are involved in a
belong to a large superfamily of transmembrane proteins called voltage-gated cation channel (VGCC) superfamily1. In addition to the ion channel families listed above, there are several more families within VGCC superfamily, including two families of the calcium-activated potassium channels, i.e., ...