Fast opening and closing of voltage-gated sodium channels are crucial for proper propagation of the action potential through excitable tissues. Unlike potassium channels, sodium channel α-subunits are believed
were sensitive to BUM – a NKCC1 blocker and EPL – a mineralocorticoid receptor blocker; indicating the involvement of NKCC1 mediated by the ALD-receptor complex. Taken together, these findings implicate NKCC1 as an important ion channel transporter for modulation of voltage-gated potassium currents...
Coexpression of KCNE1 does not change TMEM16A to a voltage gated Cl- channel and C a2+-dependent regulation of TMEM16A is fully maintained in the presence of KCNE1. While overexpressed KCNE1 slightly affects Ca2+-dependent regulation of TMEM16A, the data provide no evidence for ...
Voltage-gated Na+ channels are essential for the functioning of cardiovascular, muscular, and nervous systems. The α-subunit of eukaryotic Na+ channel consists of ~ 2000 amino acid residues and encloses 24 transmembrane (TM) helices, which form five membrane domains: four voltage-sensing (VSD)...
Findings derived from the study of Hv channels, a minimal voltage-gated channel, may offer principles common to other larger and more complex ion channels; force transmission between the cytoplasmic domain and the gate within the transmembrane region may also occur in other ion channels in which ...