Fast opening and closing of voltage-gated sodium channels are crucial for proper propagation of the action potential through excitable tissues. Unlike potassium channels, sodium channel α-subunits are believed to form functional monomers. Yet, an increasing body of literature shows inconsistency with th...
were sensitive to BUM – a NKCC1 blocker and EPL – a mineralocorticoid receptor blocker; indicating the involvement of NKCC1 mediated by the ALD-receptor complex. Taken together, these findings implicate NKCC1 as an important ion channel transporter for modulation of voltage-gated potassium currents...
Findings derived from the study of Hv channels, a minimal voltage-gated channel, may offer principles common to other larger and more complex ion channels; force transmission between the cytoplasmic domain and the gate within the transmembrane region may also occur in other ion channels in which ...
To analyze the current-voltage characteristics, we used the corrected potential drop Δφ’, equal to the measured value of the total potential drop minus the ohmic component [40,41]. The limiting diffusion current density ilim was determined as the point of intersection of the limiting current ...
The amount of Ca2+/CaM complex in the subspace is greater during pacing at 8 Hz compared to acing at 1 Hz pacing leading to increased Ca-dependent inactivation of the L-type channel. Figure A3. The amount of Ca2+/CaM complex in the subspace is greater during pacing at 8 Hz compared ...