The voltage-gated potassium channel K V 1.3 is an important therapeutic target for the treatment of autoimmune and neuroinflammatory diseases. The recent structures of K V 1.3, Shaker-IR (wild-type and inactivating W434F mutant) and an inactivating mutant of rat K V 1.2-K V 2.1 paddle ...
Kv2.1为电压依赖性外向型钾通道(Voltage-gated potassium channel),通常以簇团样分布于细胞膜表面调节细胞的兴奋性,已有研 … www.chemyq.com|基于2个网页 3. 电压依赖性门控钾离子通道 ...象是普遍存在于神经系统各个神经元的名为Kv2.1的电压依赖性门控钾离子通道(voltage-gated potassium channel)。
calcium- and sodium- activated potassium channels (KCa, KNa), cyclic nucleotide-gated (CNG) channels, hyperpolarization-gated (HCN) channels, and cation sperm-specific (CatSper) channels are tetramers of such 6TM subunits.Fig. 2Ashows the structure of a prototypical voltage-gated K+...
voltage-gated potassium channel 专业医学词典 电压门控性钾通道 与"voltage-gated potassium channel"相近的词条 ... voltage-gated channel voltage-gated channels voltage-gated ion channel voltage-gated ion channel protein voltage-gated ion channels voltage-gated potassium channel voltage gradient voltage indic...
Towards the three-dimensional structure of voltage-gated potassium channelsdoi:10.1016/S0968-0004(99)01440-1Potassium channelsProtein structureIon selectivityChannelElectrical excitability is a fundamental property of the neuromuscular systems of metazoans. The varied response of neurons to electrical ...
Computational identification of residues that modulate voltage sensitivity of voltage-gated potassium channels p pBackground/p pStudies of the structure-function relationship in proteins for which no 3D structure is available are often based on inspection of multipl... B Li,WJ Gallin - 《Bmc Struc...
Kv1.3 channel plays an important role in the activation, migration, proliferation and cytokine secretion of T lymphocytes. By regulating the opening and closing of potassium channels, it can regulate the signal transduction pathway, furthermore regulate activation,differentiation,inflammatory secretion of ...
Cancer antigen 125 (CA125), also referred to as mucin 16, is expressed under both normal and pathological conditions and the complexity of its structure indicates multifunctionality, i.e. both the protein and carbohydrate parts may be involved in diverse interactions at different levels of cell ...
Voltage-gated channels open paths for ion permeation upon changes in membrane potential, but how voltage changes are coupled to gating is not entirely understood. Two modules can be recognized in voltage-gated potassium channels, one responsible for volt
The crystal structure of Kv1.2, a voltage-gated potassium channel from rat brain, provided the first atomic-resolution structure of a voltage-gated potassium channel, in which the ion conduction gate is open. The studies presented in this dissertation use molecular dynamics simulations to investigate...