Voltage-gated sodium channels are expressed across excitable cells where they are crucial for sharp initiation dynamics and propagation of the action potential1. TheSCN5Agene encodes for the cardiac sodium channel α-subunit, Nav1.5.SCN5Amutations have been linked to cardiac arrhythmias such as Brugad...
Findings derived from the study of Hv channels, a minimal voltage-gated channel, may offer principles common to other larger and more complex ion channels; force transmission between the cytoplasmic domain and the gate within the transmembrane region may also occur in other ion channels in which ...
were sensitive to BUM – a NKCC1 blocker and EPL – a mineralocorticoid receptor blocker; indicating the involvement of NKCC1 mediated by the ALD-receptor complex. Taken together, these findings implicate NKCC1 as an important ion channel transporter for modulation of voltage-gated potassium currents...
2.1.7. Calcium Buffers The three endogenous buffers of calmodulin (CaM), troponin (Trpn), and the phospholipids of the SR membrane (SRbuf) are used for the bulk myoplasm. The troponin complex consists of three different subunits. The troponin complex as modeled includes the binding of calcium...