Voltage-gated sodium channels are expressed across excitable cells where they are crucial for sharp initiation dynamics and propagation of the action potential1. TheSCN5Agene encodes for the cardiac sodium chan
Voltage-gated Na+ channels are essential for the functioning of cardiovascular, muscular, and nervous systems. The α-subunit of eukaryotic Na+ channel consists of ~ 2000 amino acid residues and encloses 24 transmembrane (TM) helices, which form five membrane domains: four voltage-sensing (VSD)...
Findings derived from the study of Hv channels, a minimal voltage-gated channel, may offer principles common to other larger and more complex ion channels; force transmission between the cytoplasmic domain and the gate within the transmembrane region may also occur in other ion channels in which ...
(p<0.05; unpaired t-test) A C E B D F 1001 Results KCNE1 does not convert TMEM16A into a voltage‑dependent Cl‑ channel, but marginally increases activation of TMEM16A by intracellular Ca2+ TMEM16A is a voltage and C a2+ gated C l- channel [38]. ...
It appears that taking into account the physical size of the VDAC lumen minus ∼0.35 nm of hydration water layer at the lumen wall gives a possibility to calculate the channel conductance with a good agreement with measured values. There is clearly much yet to be learned about the structural...
were sensitive to BUM – a NKCC1 blocker and EPL – a mineralocorticoid receptor blocker; indicating the involvement of NKCC1 mediated by the ALD-receptor complex. Taken together, these findings implicate NKCC1 as an important ion channel transporter for modulation of voltage-gated potassium currents...