Based on an adaptation of the extensively validated PrePPI algorithm (predicting protein-protein interactions) (Garzón et al., 2016, Zhang et al., 2012), P-HIPSTer (pathogen-host interactome prediction using structure similarity) exploits protein structural information, taken from the Protein Data Ba...
Structural analysis revealed that Ebola virus L possesses a filovirus-specific insertion element that is essential for RNA synthesis, and that VP35 interacts extensively with the N-terminal region of L by three protomers of the VP35 tetramer. Notably, we captured the complex structure in a ...
Viral RNAs harbour a conserved 3′ structure essential for RNA replication initiation. After mechanical transmission to laboratory test plants, beet necrotic yellow vein virus (BNYVV) RNAs 3, 4 and 5 may carry deletions or may be lost entirely. The complete sequence has been determined for all ...
structure, indicative of receptor switching driving viral evolution and subsequent viral classification. Consequently, viral receptor usage is a determinant for cell tropism and its evolution can change virus targets at the level of cells to host ranges. Although virus–receptor interactions have been ...
It is also important to know that the Chinese economy is not what it was 17 years ago. It is bigger, healthier and more balanced in structure. Although the virus keeps people out of shops, restaurants, theaters and travel hubs, reduction in offline sales will likely be offset to some exte...
gene expression, with the microcosm and location analyses also well-powered to detect smaller changes in expression. Therefore, in differential expression analyses that return a low number or no DEGs, there is a reasonable level of confidence that this is due to a lack of differential expression....
This will usually be a hierarchical structure headed by a director or head of department, with section or unit heads, a laboratory manager, and range of health-care scientists of different grades. One individual should take the lead for quality; this could be either a dedicated role or an ...
[63,64,65]. In addition, a limitation for all of our samples is that we can only compare diversity measurements from iSNVs greater than 3% frequency, and iSNVs below this threshold may be important for the virus population structure and phenotype [5,11,66]. Even still, our incongruent ...
a, Structure-based sequence alignment with the labelled secondary structure of various LA domains, including mouse (m) LDLRAD3 domains 1–3, human (h) LDLR CR2 and CR3 (PDB: 5OYL and 5OY9, respectively31), and human VLDLR-V3 (PDB: 3DPR; ref. 33). Contact residues of LDLRAD3(D1...
et al. Relationship of the quaternary structure of human secretory IgA to neutralization of influenza virus. Proc. Natl Acad. Sci. USA 112, 7809–7814 (2015). Article CAS PubMed PubMed Central Google Scholar Ekiert, D. C. et al. Cross-neutralization of influenza A viruses mediated by a...