A Virus Antibody is an immune protein produced in response to a virus or its components, such as virions or virion proteins, to trigger a defense mechanism in the host's immune system. AI generated definition based on: Viruses, 2018
Mechanism of human antibody-mediated neutralization of Marburg virus. Cell 2015, 160, 893-903. [CrossRef] [PubMed]Flyak, A.I.; Ilinykh, P.A.; Murin, C.D.; Garron, T.; Shen, X.; Fusco, M.L.; Hashiguchi, T.; Bornholdt, Z.A.; Slaughter, J.C.; Sapparapu, G.; et al. ...
While oligonucleotides containing LNAs strengthen binding to nucleic acid targets,38 STOPS like ALG-10000 may be too conformationally stiff to form intramolecular base pairs, or base pair with another ALG-10000 molecule. All of the chemical features of STOPS appear to contribute to their mechanism ...
To exclude that the mutations in the M-domain cause structural changes in E proteins we performed neutralization assays, assuming that structural changes in E would alter accessibility of epitopes to neutralizing antibodies. To this end, we used the E-neutralizing monoclonal antibody 4G2 that recogni...
Protein-protein interactions featuring intricate binding epitopes remain challenging targets for synthetic inhibitors. Interactions of NEMO, a scaffolding protein central to NF-κB signaling, exemplify this challenge. Various regulators are known to inte
Antibody-dependent cellular cytotoxicity in HIV infections. ADCC is an important immune effector mechanism against and virus-infected that can be destroyed by the combined action of specific of IgG isotype against -... A Ahmad,J Menezes - 《Faseb Journal Official Publication of the Federation of ...
(mGluR2) as its receptor protein, which is highly expressed in the CNS [26]. This finding provides valuable insights into the molecular mechanism of neurotropism of the virus. Another neurotropic virus, the porcine hemagglutinating encephalomyelitis virus (PHEV), has been found to bind neural ...
Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin. PNAS. 2011;108(34):14216–21. Article CAS PubMed PubMed Central Google Scholar Mozdzanowska K, Maiese K, Furchner M, Gerhard W. Treatment of influenza virus-infected SCID mice with...
antibodyand thep24 antigen, and the fifth generation additionally differentiates between antibody and antigen allowing assessing the acuteness of the infection and also differentiates between HIV-1 and HIV-2. Both of these new assays decrease the window period almost to the extent of molecular testing...
binding mAbs such as CR8071 do not interfere with HA binding to sialic acid receptors on effector cells and are more likely to induce Fc-dependent effector functions15. However, owing to the less-functional importance of the esterase domain compared with the HA stalk, antibody-resistant viruses ...