The life cycle of SARS-CoV-2 has not been rigorously established; however, given the considerablesequence homology, it is presumed to be similar to that of SARS-CoV-1 and other CoVs (4,5). In general, the CoV life cycle consists of a series of steps that begins with viral binding to...
Sequencing SARS-CoV-2 with the xGen Amplicon workflow Due to the speed with which variants of SARS-CoV-2 have appeared, researchers have had to repeatedly change methods to effectively track SARS-CoV-2 variants. Despite the ever-emerging variants of SARS-CoV-2, the xGen SARS-CoV...
Both S-HT and S-A participants had diminished SARS-CoV-2鈥搒pecific humoral responses, whereas only the S-HT group had reduced T cell鈥搈ediated responses. This highlights the varied risk of persistent COVID-19 across distinct immunosuppressive conditions and sugge...
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the ongoing global pandemic that poses substantial challenges to public health worldwide. A subset of COVID-19 patients experience systemic in
Depending on the pattern of ACE2 expression, the SARS-CoV-2 spike (S) protein induced high levels of Interleukin 6 in healthy donor-derived primary airway epithelial cells, but a very weak response in primary Cystic Fibrosis cells. Collectively, these data support that Cystic Fibrosis condition ...
Since the first occurrence of the SARS-CoV-2 infection, a wide variety of drug compounds affecting the binding sites of the virus have begun to be studied. As the drug and vaccine trials are continuing, it is of utmost importance to take into consideration the SARS-CoV-2 mutations and thei...
PacBio宣布推出HiFiViral SARS-CoV-2试剂盒。这是一种装备齐全的COVID-19监测端到端解决方案,公共卫生实验室可以使用它来识别新的SARS-CoV-2变异,并检测人群中传播的所有变异。 HiFiViral SARS-CoV-2试剂盒是PacBio公司提出的首个用于COVID-19变异基因组监测的成套解决方案。该分析利用PacBio可信的HiFi测序技术,...
In this issue of JAMA, Zhang and colleagues report the emergence of a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant in
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been a devastating global pandemic for 4years and is now an endemic disease. With the emergence of new viral variants, COVID-19 is a continuing threat to public health ...
SARS-CoV-2 surveillance by wastewater-based epidemiology is poised to provide a complementary approach to sequencing individual cases. However, robust quantification of variants and de novo detection of emerging variants remains challenging for existing strategies. We deep sequenced 3,413 wastewater samples...