[7]. Lucy Gossage , Tim Eisen, Eamonn R Maher.VHL, the story of a tumour suppressor gene[J]. Nat Rev Cancer. 2015 Jan;15(1):55-64. doi: 10.1038/nrc3844. [8]. R.Srinivasan,et al. Belzutifan, a HIF-2α Inhibitor, for von...
病因学:目前已知血管母细胞瘤是由于第三对体染色体上一个抑制肿瘤基因(VHL)出现异常所致。VHL基因是肿瘤抑制基因(tumor suppressor gene),这意味着此基因功能不良将使细胞以不受控制的方式生长和分裂过快。VHL protein的改变或缺乏将使其无法有效地调节细胞的存活或分裂,因此细胞的生长和分裂会失去控制进而形成肿瘤和囊...
tumorsuppressorgenecancerhumankidneyretinoblastomatranscriptioncellcycleThe VHL tumour-suppressor gene (TSG) has a critical `gatekeeper' role in regulating growth and differentiation of human kidney cells, and inactivation of the VHL gene is the most frequent genetic event in human kidney cancer. There ...
The evidence from cancer cell lines and primary tumor tissues suggests that WWOX is a tumor suppressor gene and that its inactivation contributes to cancer devel. 原发肿瘤组织及细胞系的研究证明该基因为肿瘤抑制基因,其失活可能导致肿瘤的发生,基因敲除实验证实了上述假设。
2024年4月,The Journal of Clinical Investigation杂志发表了题为“Von Hippel Lindau tumor suppressor controls m6A-dependent gene expression in renal tumorigenesis”的研究,填补了VHL在ccRCC中m6A模式影响作用的研究空白。 研究方法 该研究是一...
Reports on the inactivation of the von Hippel-Lindau (VHL) tumor-suppressor gene which is linked to the development of different tumor types in humans. Finding that the disruption of the microtubule stabilization function of the VHL is linked to the development of a specific subtype of VHL ...
VHL, the story of a tumour suppressor gene. Nat Rev Cancer. 2015;15:55–64. Article CAS PubMed Google Scholar Wang Y, Li G, Deng M, Liu X, Huang W, Zhang Y, et al. The multifaceted functions of RNA helicases in the adaptive cellular response to hypoxia: from mechanisms to ...
Mutations of the VHL tumor suppressor gene are associated with a variety of tumors such as renal clear cell carcinomas (RCC). In this study, we ... Krieg,Marion,Haas,... - 《Oncogene》 被引量: 484发表: 2000年 VHL tumor suppressor gene alterations associated with good prognosis in sporadi...
VHL(von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase) 基因基本信息 基因简称(symbol) VHL [HGNC] [GeneCards] [NCBI] 基因种类(locus group) protein-coding gene 同源简称(alias symbol) VHL1 基因家族代码(gene_family_id) [HGNC] [GenScript] omim代码 608537 entrez码 7428 [...
In spite of the general recognition of von Hippel-Lindau (VHL) as a tumor suppressor gene, the physiological and pathological importance of VHL protein in cell growth regulation and tumorigenesis remains unclear. Here we show that in normal human renal proximal tubule epithelial cells (RPTEC), ...