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and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also re...
Article CAS PubMed PubMed Central Google Scholar Wizigmann-Voos, S., Breier, G., Risau, W. & Plate, K. H. Up-regulation of vascular endothelial growth factor and its receptors in von Hippel–Lindau disease-associated and sporadic hemangioblastomas. Cancer Res. 55, 1358–1364 (1995)....
As a result, we identified 4,282 and 3,585 proteins, respectively, in the pooled cell lysates of RCC4 and 786-O cells (Supplementary Data 1,2). All quantification data were normalized and natural log transformed before further analysis. Differentially expressed proteins were determined by applyi...
in VHL patients are hemangioblastomas of the retina or optic nerve head. A hemangioblastoma is any case of angiomatosis, a proliferation of vascular endothelium, within the central nervous system. Retinal capillary hemangioblastomas are found in up to 70 % of VHL patients by 60 years of...
PubMed PubMed Central Google Scholar Farré D, Roset R, Huerta M, Adsuara JE, Roselló L, Albà MM et al. Identification of patterns in biological sequences at the ALGGEN server: PROMO and MALGEN. Nucleic Acids Res 2003; 31: 3651–3653. Article Google Scholar Lu W, Lakonishok M,...
28., 51. Recognizing that this primary type PPI could be suitably targeted by small-molecule disruptors, in pioneering work, our laboratory in collaboration with the Crews laboratory developed a first-generation of VHL ligands with single-digit micromolar binding affinities based around the central ...
Given the central role of VHL in hypoxic gene regulation and in renal cancer formation, we wished to examine the VHL-dependent regulation of miRNAs in renal cancer. miRNA dysregulation has been observed in renal cancer, and miR-210 has been identified as a hypoxia and VHL-regulated miRNA in ...
The von Hippel–Lindau (VHL) tumor suppressor is a multisubunit Cullin RING E3 ligase (CRL2VHL)—composed of Cullin2 as the central scaffold subunit, Rbx1 as RING subunit, ElonginB and ElonginC as adaptor subunits, and VHL as substrate recognition subunit (1, 2). VHL functions to specifica...
BJRW go on to prove the same is true for whatever other scientific fields they care to measure. Measuring scientific progress is inherently difficult, but their finding of constant or log-constant progress in most areas accords withNintil’s overview of the same topic, which gives us graphs ...