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(SPSS Institute). The Pearson’sχ2test was used to evaluate the correlation among the protein expression of VHL, HNF-4α and ALDH2 in immunochemical assay. Unless described otherwise thePvalues for comparison between line-linked groups were obtained by Student’s two-sidedt-test. The ...
neoplastic disease that affects approximately 1/36000–45,500 live births [1,2]. VHL disease encompasses various types of tumors, including retinal or central nervous system hemangioblastoma (RH or CNSH), clear cell renal cell carcinoma (RCC), pheochromocytoma (PHE), multiple pancreatic cysts or...
we detected the expression of FBXO22 in three GBM cell lines (U87, LN229, and U373) by Western blot assays. We found that FBXO22 expression was much higher in LN229 and U373 cells than in U87 cells (Fig.2A). Therefore,
J. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol. Cell 30, 393–402 (2008). 7. Majmundar, A. J., Wong, W. J. & Simon, M. C. Hypoxia-inducible factors and the response to hypoxic stress. Mol. Cell 40, 294–309 (2010). 8. Kamura, T. et...
significantly higher than that of VH032 (Table 1), in line with the increase in LogD7.4, suggesting that VH298 can move through cell membranes more efficiently, leading to an increase on available inhibitor in cells. We next examined potential cytotoxicity of VH298 and VH032 in a range of...
Central Military Hospital Utrecht, Lundlaan 1, 3584 EZ Utrecht, The Netherlands 7 UMC Utrecht Regenerative Medicine Center, University Medical Center, 3584 CT Utrecht, The Netherlands * Authors to whom correspondence should be addressed. † These authors contributed equally to this work.Cells...