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2]. VHL disease encompasses various types of tumors, including retinal or central nervous system hemangioblastoma (RH or CNSH), clear cell renal cell carcinoma (RCC), pheochromocytoma (PHE), multiple pancreatic cysts or tumors (PCT
J. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol. Cell 30, 393–402 (2008). 7. Majmundar, A. J., Wong, W. J. & Simon, M. C. Hypoxia-inducible factors and the response to hypoxic stress. Mol. Cell 40, 294–309 (2010). 8. Kamura, T. et...
To evaluate the cellular activity of VH298, we first assessed its cell permeability by performing PAMPA (parallel artificial membrane permeability assay) using a filter plate pre-coated with structured layers of phospholipids. We also measured the compounds’ lipophilicity at physiological pH (LogD7.4)...
PubMed CentralGoogle Scholar Allred, D. C., Brown, P. & Medina, D. The origins of estrogen receptor alpha-positive and estrogen receptor alpha-negative human breast cancer.Breast Cancer Res.6, 240–245 (2004). CASPubMedPubMed CentralGoogle Scholar ...