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VHL-regulated miRNA profiling We performed small RNA sequencing in the VHL-deficient ccRCC cell line, RCC4, and its isogenic counterparts expressing a functioning VHL protein, RCC4 VHL. Of the 352 miRNAs quantified, 75 were differentially expressed (DE), including 47 upregulated and 28 downregulat...
Numerical simulations are used to showcase the efficiency of the derived parameters, while also illustrating the constraints that should be taken into account. The importance of the type VI secretion system (T6SS) in interbacterial competition and virulence characteristics is evident in Vibrio species...
(column normalization) so that the sum of the signal for all protein in each channel was equal to account for sample loading. Mass spectrometry-based proteomics raw data files have been deposited to the ProteomeXchange Consortium via the PRIDE45,46partner repository (PXD018937). Gene Set ...
Central alveolar hypoventilation and impaired autonomic function are hallmarks of congenital central hypoventilation syndrome (CCHS), a rare disease attributable to pathogenic variants.The gene's presence is essential for all forms of life's activities. A polyalanine repeat mutation (PARM) in the hetero...