Therapeutic drug monitoring/range: 10 to 20 mcg/mL (trough) AAP, ASHP, IDSA, PIDS, and SIDP Recommendations: Patients with suspected/definitive serious MRSA infections: 24-hour AUC level of 400 to 600 mg*hr/L (assuming a drug MIC of 1 mg/L) Trough levels (1 to 2 hours after dosing...
The vancomycin peak and trough are two extremes of concentration of vancomycin in a person's bloodstream. It's important to know...
Trough-only monitoring, with a target of 15–20 mg/L, is no longer recommended based on efficacy and nephrotoxicity data in patients with serious infections due to MRSA.Current guidelines recommend AUC-guided therapeutic monitoring of vancomycin in both adults and pediatric patients with serious MRSA...
In dogs, to maintain the plasma concentration between a suggested range of 10 and 30 mcg/mL, the dose rate of 15 mg/kg q8h IV is recommended. (This dose actually produces peaks and troughs of approximately 40 and 5 mcg/mL, respectively, but it is the most convenient dose that ...
However, in patients with normal serumcreatinine (SCr), monitoring of VCM-serum concentrations is disputable. We retrospectively studied 19 patients (age 51 +- 19 years, 12 women) who had a 50% increase of their normal baseline SCr (ARF) during VCM therapy. Trough serum concentration of VCM...
Reference range: Trough concentration C0: 10-15 mg/L in adult patients with common infections; 10-20 mg/L in adult patients with severe MRSA infections; for neonatal/pediatric patients, it is recommended that vancomycin trough concentrations be maintained at 5-15 mg/L. Alternatively, a target ...
The majority of the sample (69.3%, n = 61) treated with the initial MAG recommended vancomycin dose (40 mg/kg/day q6-8 h) had a trough level within the wide therapeutic range (7–20 mg/L), the majority of which (75.4%, 46) had a low range trough level (7–15 mg/L). ...
Vancomycin, a branched tricyclic glycosylated peptide antibiotic, is a last-line defence against serious infections caused by staphylococci, enterococci and other Gram-positive bacteria. Orally-administered vancomycin is the drug of choice to treat pseud
8. plasma concentration should be monitored during treatment; the peak concentration should not exceed 25~40μg/ml, trough concentration should not exceed 5~10μg/ml. Concentration higher than 60μg/ml is within the range of poisoning. If you can’t monitor the blood concentration, adjust the...
Vancomycin Trough Concentrations Among Recipients of Vancomycin Plus Piperacillin/Tazobactam or Vancomycin Plus Other Antipseudomonal Beta-Lactam Agents eTable 4. Sensitivity Analysis of the Effect of an Unmeasured Confounder on the Association Between Combination Therapy Group and AA-AKI eTable 5. Multip...