The new 2019 draft of therevised vancomycin therapeutic guidelinesrecommends a move away from monitoring vancomycin trough levels and towards a metric that measures total drug exposure in relation to the organism’s minimum inhibitory concentration. This is referred to as anAUC24:MIC(24-hour area un...
5–10 mg/l to 10–15 mg/l however the recommended dose remained the same.1 This has necessitated doses to be given in excess of the BNFc and licensed doses; this audit looks at the current paediatric guidelines and practice to determine whether these trough levels are being achieved...
Dosing Considerations Peak values 18-26 mg/L; trough values 5-10 mg/L; however, Infectious Diseases Society of America and other guidelines urge troughs 15-20 mg/L Only treat or prevent infections proven or strongly suspected to be caused by susceptible bacteria to reduce development of drug-...
After the guidelines were implemented, patients were dosed on actual body weight (ABW), lS-20mg/kg, or 2S-30mg/kg in seriously ill patients, every 8-12 hours. We compared the frequency of achieving therapeutic troughs, nephrotoxicity and trough group levels stratified by Body Mass Index (...
Vancomycin dosing guidelines recommend area-under-the-cure (AUC) over trough-based dosing for severe MRSA infections. Optimal dosing of non-severe or non-MRSA is unknown. Conflicting data exists on the real-world benefits of implementing AUC-based dosing methods. METHODS. A standardized vancomycin ...
Overall, our results of lower microbiologic failure and possibly lower treatment failure in the high-vancomycin group support IDSA recommendations for maintaining trough levels of >15 mg/L in the treatment of severe MRSA infections [45], [50]. As noted in the guidelines, higher vancomycin levels...
According to the MAG, serum trough levels are usually obtained 15–30 min before the fourth dose for patients receiving the drug at an interval less than 24 h; otherwise, it is tested before the third dose if the dosing interval is 24 h or longer. The level is repeated every 5–7 ...
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although these targets are derived from adult data.64Guidelines from the Infectious Diseases Society of America recommend similar trough targets in pediatric patients.65The current initial recommendations are displayed inTable I, and close monitoring of trough levels and adjusting them accordingly are ofte...
Current guidelines for the empiric treatment of ventilator-associated pneumonia (VAP) recommend that vancomycin is dosed 15 mg/kg and administered twice daily for a target trough level of 15 to 20 μg/mL. This study compared conventional intermittent vancomycin infusion (IVI) with continuous vancomy...