troughvancomycinThe aim of our study was to investigate the association between vancomycin trough level and clinical outcomes (mortality and nephrotoxicity) among infected pediatric patients with Gram-positive pathogens. We systematically searched the Scopus, EMBASE, Cochrane Central Register of Controlled ...
The equation that characterizes the study population was obtained based on a single compartment model considering the proportional relationship between vancomycin and creatinine clearance. The analysis shows that only 44% of C(trough) and 47% of C(peak) values represented therapeutic levels, with the...
Vancomycin serum levels (Cmin and Cpeak), t and Vd were determined in 1 month to 12 year old patients receiving ≥ 40 mg per-kg-per day. Plasmatic levels were measured at therapy onset and during follow up, evaluating the proportion of trough level determinations within therapeutic range, ...
The process used today involves numerous inputs from various experts. The Vancomycin trough test alone costs over $100 per test Dose individualisation to enhance drug efficacy & reduce adverse side effects Current dosing models generalise everyone's health profile based on the population rather than...
The process used today involves numerous inputs from various experts. The Vancomycin trough test alone costs over $100 per test Dose individualisation to enhance drug efficacy & reduce adverse side effects Current dosing models generalise everyone's health profile based on the population rather than...
AUC estimation using trough and peak levels produced the least bias in patients treated with vancomycin q12h. Conversely, AUC estimation using only the trough level produced moderate and strong bias in patients treated with vancomycin q12h and q24h, respectively. The committee also evaluated ...
10-40 mcg/mL Phenytoin 10-20 mcg/mL Salicylate 100-250 mcg/mL Theophylline 10-20 mcg/mL Tobramycin 5-10 mcg/mL Trough Drug Levels: Gentamicin Tobramycin Vancomycin Gentamicin: 1-2 mcg/mL Tobramycin: 1-2 mcg/mL Vancomycin: 15-20 mcg/mL...
vancomycin and few antibioticsimmunoassaysare not commercially available, and only chromatographic methods can be applied for their monitoring in human serum or plasma. Because of complex nature of chromatographic techniques, small- to medium-size laboratories do not have the capability of using such met...
Once the initial regimen is administered, vancomycin trough is usually monitored. The 2009 Vancomycin consensus guidelines proposed a target steady-state trough of 15-20 mg/L for serious infections when the MIC is ≤1mg/L and...
Validation of A Nomogram for Achieving Target Trough Concentration of Vancomycin: Accuracy in Patients with Augmented Renal Function. Adjustment of initial vancomycin (VCM) dosage has been recommended on the basis of the renal function nomogram in therapeutic drug monitoring guidelines in... Hidetoshi,...