Gabapentin, valproic acid, and ethanol intoxication: elevated blood levels with mild clinical effects. J Toxicol Clin Toxicol 1996;34(4):437-9.Fernandez MC, Walter FG, Petersen LR, Walkotte SM (1996) Gabapentin, valproic acid, and ethanol intoxication: elevated blood levels with mild clinical ...
The method was successfully tested with amaranth and then applied to valproic acid serum levels. AUC and mean serum levels were determined by the standard procedure of assays of multiple samples and the trapezoidal rule. Mean serum level was also determined by the pooled sample technique. The ...
A stability study of valproic acid in postmortem blood was conducted, showing a decline of valproic acid levels by 85 % after storage at room temperature for 28 days. During the storage time, the blood samples showed changes in consistency. Depending on the stage of decomposition, it is ...
whole blood was collected and serum was analyzed for VPA,liver function tests(transaminases) and complete blood count.The DNA strand breaks were identified by the terminal deoxynucleotidyltransferase-mediated UTP end labeling technique using the in situ Cell Death Detection Kit.Effects of VPA on ...
Serum levels of carbamazepine (CBZ) decreased 17% while that of carbamazepine-10,11-epoxide (CBZ-E) increased by 45% upon co-administration of valproate and CBZ to epileptic patients. Clonazepam The concomitant use of valproic acid and clonazepam may induce absence status in patients with a hist...
Neuroprotection by valproic acid in an intrastriatal rotenone model of Parkinson's disease. Neuroscience. 2014; 267:114-121. [PubMed: 24613722]Carriere, C.H.; Kang, N.H.; Niles, L.P. Neuroprotection by valproic acid in an intrastriatal rotenone model of Parkinson's disease. Neuroscience ...
Since plasma protein-bound valproate is available for uptake by brain, the major factor underlying the diminished distribution of the drug in brain appears to be the asymmetric transport properties of the BBB to valproic acid. 展开 关键词: Blood-brain barrier polarity Valproic acid Serum protein ...
The abnormality rate of laboratory indexes in different age groups after long term VPA; VPA: Valproic acid. a-g different test trends. a the trend of variation of ALT levels in different age groups. b the AST levels decreased as age increased. P < 0.001. c the trend of variation of...
Valproic acid drug interactions (more detail)Test InteractionsMay cause a false-positive result for urine ketones (valproate partially eliminated as a keto-metabolite in the urine); may alter thyroid function testsAdverse ReactionsThe following adverse drug reactions and incidences are derived from ...
As the Valproic acid dosage is titrated upward, blood concentrations of phenobarbital and/or phenytoin may be affected [see Drug Interactions ( 7.2)] . Antiepilepsy drugs should not be abruptly discontinued in patients in whom the drug is administered to prevent major seizures because of the str...