activity through the switching probability of the proton-pumping mode. By contrast, electrochemical proton gradients regulate the pumping rate and the switching of the pumping and inactive modes. A direct consequence of mode-switching is all-or-none stochastic fluctuations in the electrochemical gradient...
7. L. Xu et al., Inhibition of host vacuolar H+-ATPase activity by a Legionella pneumophila effector. PLoS Pathog 6, e1000822 (2010). 8. S. H. Roh et al., The 3.5-A CryoEM Structure of Nanodisc-Reconstituted Yeast Vacuolar ATPase Vo Proton Channel. Mol Cell 69, 993-1004 e1003 ...
7. L. Xu et al., Inhibition of host vacuolar H+-ATPase activity by a Legionella pneumophila effector.PLoS Pathog6, e1000822 (2010). 8. S. H. Roh et al., The 3.5-A CryoEM Structure of Nanodisc-Reconstituted Yeast Va...
M. Hernandez, Dependence of Saccharomyces cerevisiae Golgi functions on V-ATPase activity. FEMS Yeast Res. 12, 341-350 (2012).Corbacho I, Teixido´ F, Olivero I & Herna´ndez LM (2012) Dependence of Saccharomyces cerevisiae Golgi functions on V-ATPase activity. FEMS Yeast Res 12: 341-...
原始出处:Bradleigh Whitton,Haruko Okamoto,et al.V-ATPase Inhibition Decreases Mutant Androgen Receptor Activity in Castrate-resistant Prostate Cancer. MOL CANCER April 2021 DOI:10.1158/1535-7163.MCT-20-0662 版权声明 本网站所有注明“来源:生物谷”或“来源:bioon”的文字、图片和音视频资料,版权均属于生物...
Mechanisms of regulating H+-ATPase activity: • Recycling of H+-ATPase-containing vesicles to and from the plasma membrane; • Glucose-sensitive assembly/disassembly of the holoenzyme complex. Molecular pathology H+-ATPase mutations in the A3 gene cause recessive osteopetrosis; they have been impl...
The activity of the V-ATPase is thought to be regulated by phosphorylation, protein interactions, nucleotide availability, cytosolic redox potential, and pH. Phosphorylation has been shown for VHA-C, which is the target of the kinase WNK8 in A. thaliana, and VHA-A that is phosphorylated in ...
V-ATPase activity is controlled by reversible dissociation of the V1 and V0 domains, a process termed regulated assembly, where both the catalytic and transport functions of the enzyme are inhibited upon disassembly (1, 4, 10). Regulated assembly has been best characterized in yeast, where ...
V-ATPase activity in GSC cultures was modulated using Bafilomycin A1 (BafA1) and cell viability and metabolic traits were analyzed using live assays. The GBM patients-derived orthotopic xenografts were used as in vivo models of disease. Cell extracts, proximity-ligation assay and advanced microscopy...
V-ATPase subunit VHA-a3 The protein is essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes and required for assembly and activity of the V-ATPase. Involved in vacuolar nutrient storage (e.g. accumulation...