For this reason, its activity is tightly regulated, and various factors, such as signaling molecules and phytohormones, may be involved in this process. The aim of this study was to explain the role of jasmonic acid (JA) in the signaling pathways responsible for the re...
Reversible Association between the V1and V0 Domains of Yeast Vacuolar H+-ATPase Is an Unconventional Glucose-Induced Effect The yeast vacuolar H+-ATPase (V-ATPase) is a multisubunit complex responsible for organelle acidification. The enzyme is structurally organized into two ma......
In this Review, we discuss recent advances in our understanding of the types of RNA sensed by RLRs in the contexts of viral infection, malignancies and autoimmune diseases. We further describe how the activity of RLRs is controlled by host regulatory mechanisms, including RLR-interacting proteins,...
Inhibition of host vacuolar H+-ATPase activity by a Legionella pneumophila effector. PLoS Pathog. 6, e1000822 (2010). Article Google Scholar Sheedlo, M. J. et al. Structural basis of substrate recognition by a bacterial deubiquitinase important for dynamics of phagosome ubiquitination. Proc. ...
Using two different GFP-based proteasome substrates, UbG76V-YFP [26] and GFP-CL1 [19], that allow us to monitor the functionality of UPS as well as measure the catalytic activities of proteasome, we found that nucleotides via P2Y2R are able to modulate UPS activity, both in vitro and ...
Dopamine is a natriuretic hormone that acts by inhibiting tubular Na+, K(+)-ATPase activity by activation of the dopamine-1 receptor (the thick ascending limb [TAL] of Henle) or by a synergistic effect of dopamine-1 and dopamine-2 receptors (the proximal tubule). The dopamine-1 receptor ...
Regulation of NF-{kappa}B activity and inducible nitric oxide synthase by regulatory particle non-ATPase subunit 13 (Rpn13) [Medical_Sciences] Human Rpn13, also known as adhesion regulating molecule 1 (ADRM1), was recently identified as a novel 19S proteasome cap-associated protein,... H Rpn...
indicating that the kinase domain is not necessary for THE1 activation in cellulose deficient plants but for reducing its activity (Merz et al.2017). Intriguingly thethe1-3allele contains a T-DNA insertion 120 bases downstream from thethe1-4insertion site and results in a loss-of-function all...
R. A unified model for the function of YTHDF proteins in regulating m6A-modified mRNA. Cell 181, 1582–1595 (2020). Article CAS PubMed PubMed Central Google Scholar Liu, J. et al. m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial ...
We conclude that despite its lack of detectable impact on global pHi regulation after acid loading in PDAC cells, V-ATPase activity, and specifically a3, is important for motility, invasion and growth/survival signaling in PDAC cells. Key words: pancreatic ductal adenocarcinoma; PDAC; PKB; Akt,...