描述USP22-IN-1 is a ubiquitin-specific peptidase 22 (USP22) inhibitor that can be used to treat proliferative diseases or cancer. 体外活性USP22-IN-1(USP22i-S02)作为一种特异性的USP22抑制剂。(i)USP22i-S02(10 ug/mL)能够抑制Treg的抑制功能。[2] ...
Regulator of calcineurin 1 (RCAN1; also known as DSCR1 or MCIP1) functions as an endogenous inhibitor of calcineurin signaling. In the present study, we have identified a novel interaction between USP22 and RCAN1 (RCAN1–1S) in the mammalian cells. In addition, the overexpression of USP22...
Briefly, cells were lysed in E1A lysis buffer (250 mM NaCl, 50 mM HEPES [pH 7.5], 0.1% NP-40, 5 mM EDTA, protease inhibitor cocktail [Sigma]). The antibodies to USP22 and PPARγ were used for immunoprecipitation. HEK293T cells were transfected with SFB-tagged protein and ...
The proteasome-specific inhibitor MG132 rescued the HIF-1α protein from degradation in MYH9 knockdown cells (Fig. 3j; Supplementary Fig. 3h). Furthermore, MYH9 knockdown significantly enhanced polyubiquitination-induced HIF-1α degradation (Fig. 3k), while MYH9 overexpression significantly inhibited ub...
A casein kinase-2 (CK2) inhibitor and a USP22 inhibitor effectively reversed LR in vivo and in vitro. Therefore, the p-MYH9 (Ser1943)/USP22/HIF-1α axis is critical for LR and cancer stemness. For the diagnosis and treatment of LR in HCC, p-MYH9 (Ser1943), USP22, and HIF-1α...
Furthermore, a GSK3 inhibitor tideglusib sensitizes tumor xenograft to chemotherapy in mice via KDM1A down-regulation and improves survival. Our findings demonstrate that nuclear GSK3β and USP22-mediated KDM1A stabilization is essential for glioblastoma tumorigenesis. 展开 ...
产品名称:USP14-Proteasome Inhibitor, IU1 .0订购此产品 供应商:Merck 规格:*** 目录价:1346 库存状态:3周到货 CAS编号: 应用范围:生化实验 种属来源: 相关信息: USP14 Inhibitor, IU1 1-(1-(4-Fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(pyrrolidin-1-yl)ethanone, 1-(1-(4-Fluorophenyl)-...
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Furthermore, by inducing deubiquitination and inhibiting the degradation of PTEN, USP22 could induce cyclin-dependent kinase inhibitor 1A (CDKN1A, also symboled as p21) expression in pancreatic cancer. Besides, MDM2 proto-oncogene (MDM2) inhibitor enhanced the antipancreatic cancer effects of USP22 ...
USP22 expression levels were negatively correlated with mTOR expression levels, and USP22-shRNA-mediated expression of p62, p-mTOR, TFEB, and LAMP1 was reversed by rapamycin, an inhibitor of mTOR. In vivo, USP22 silencing significantly alleviated infarct volume, neurobehavioral impairments, cell ...