Uridine diphosphate-glycosyltransferasesMalariaVector controlMalaria remains one of the highest causes of morbidity and mortality, with 249 million cases and over 608,000 deaths in 2022. Insecticides, which target theAnophelesmosquito vector, are the primary method to control malaria. The widespread ...
1. Uridine-diphosphate-N-acetylglucosamine (UDP-GlcNAc) is the sugar nucleotide donor for the synthesis of O-GlcNAc modified proteins, by O-GlcNAc transferase (OGT). OGT has a high affinity for UDP-GlcNAc, which provides it with a competitive advantage over nucleotide transporters in t...
All glycosyltransferases have a bidomain structure where the N-terminal domain binds the acceptor (aglycone) substrate and the C-terminal domain binds the donor (nucleotide diphosphate-hexose) substrate. Each domain contains a Rossmann fold motif comprised of six parallel β-sheets separated by α-...
EVIDENCE FOR CELL-SURFACE GLYCOSYLTRANSFERASES Intact chicken embryo neural retina cells have been shown to catalyze the transfer of galactose-14C from uridine diphosphate galactose (UDP-galactose) to endogenous acceptors of high molecular weight as well as to exogenous acceptors. Fo... S Roth,EJ Mcg...
Nucleotide sugars and glycosyltransferases for synthesis of cell wall matrix polysaccharides The current interest in cell wall biosynthesis is expanding because of the increasing evidence that the properties of the cell wall mediate cellular intera... DM Gibeaut - 《Plant Physiology & Biochemistry》 被...
EVIDENCE FOR CELL-SURFACE GLYCOSYLTRANSFERASES Intact chicken embryo neural retina cells have been shown to catalyze the transfer of galactose-14C from uridine diphosphate galactose (UDP-galactose) to endogenous acceptors of high molecular weight as well as to exogenous acceptors. Fo... S Roth,EJ Mcg...
Inhibitors of glycosyltransferases Nucleotide linked 2-deoxy-2-fluoroglycosides are employed as potent competitive inhibitors of glycosyltransferases. More particularly, uridine-5'-diphospho-2-deoxy-2-fluoro-galactose (UDP-2F-Gal), guanidine-5'-diphospho-2-deoxy-2-fluoro-... CH Wong,T Hayashi 被引...
(Thr98 of DeoB). Sugar diphosphates, such as Rib-1,5-diphosphate (Rib1,5diP) andd-glucose-1,6-diphosphate (Glc1,6diP), serve as catalytic activators required in low micromolar concentration82. We show that theΨMP formation rate is the same irrespective of whether Glc1,6diP (a ...
UDP-glycosyltransferases are known to catalyze the covalently link of glycosyl groups including UDP-glucuronic acid, UDP-glucose, UDP-galactose, UDP-xylose. UDP-glucuronosyltransferases are a class of UDP-glycosyltransferases utilizing UDP-glucuronic acid as the sugar donor to form glucuroni...
Notably, the inhibition of Uridine diphosphate glycosyltransferases induced a transition in body color from green to yellow in the two-spotted spider mite. While the current investigation has not completely elucidated the mechanism underlying the pigmentation disparities between the two mite...