Uridine diphosphate-glycosyltransferasesMalariaVector controlMalaria remains one of the highest causes of morbidity and mortality, with 249 million cases and over 608,000 deaths in 2022. Insecticides, which target theAnophelesmosquito vector, are the primary method to control malaria. The widespread ...
All glycosyltransferases have a bidomain structure where the N-terminal domain binds the acceptor (aglycone) substrate and the C-terminal domain binds the donor (nucleotide diphosphate-hexose) substrate. Each domain contains a Rossmann fold motif comprised of six parallel β-sheets separated by α-...
3.17.5.2Characterization and Purification of Glycosyltransferases 3.17.5.2.1Xyloglucan synthases Xyloglucan is one of the most prominent matrix polysaccharides in nongraminaceous plant cell walls, making up 20% of total primary cell wall polysaccharides. As stated earlier, it is composed of ...
EVIDENCE FOR CELL-SURFACE GLYCOSYLTRANSFERASES Intact chicken embryo neural retina cells have been shown to catalyze the transfer of galactose-14C from uridine diphosphate galactose (UDP-galactose) to endogenous acceptors of high molecular weight as well as to exogenous acceptors. Fo... S Roth,EJ Mcg...
Nucleotide sugars and glycosyltransferases for synthesis of cell wall matrix polysaccharides The current interest in cell wall biosynthesis is expanding because of the increasing evidence that the properties of the cell wall mediate cellular intera... DM Gibeaut - 《Plant Physiology & Biochemistry》 被...
EVIDENCE FOR CELL-SURFACE GLYCOSYLTRANSFERASES Intact chicken embryo neural retina cells have been shown to catalyze the transfer of galactose-14C from uridine diphosphate galactose (UDP-galactose) to endogenous acceptors of high molecular weight as well as to exogenous acceptors. Fo... S Roth,EJ Mcg...
Thiosugar nucleotide analogues:synthesis of uridine 5'-(2,3,6-tri-O-acetyl-4-S-acetyl-4-thio-#alpha#-D-galactopyranosy 1 diphosphate) The synthesis of a novel uridine diphosphoate galactose (UDP-Gal)analog,(UDP-2,3,6-tri-O-acetyl-4-S-acetyl-4-thio-#alpha-D-galactopyranose)(10) is...
(Thr98 of DeoB). Sugar diphosphates, such as Rib-1,5-diphosphate (Rib1,5diP) andd-glucose-1,6-diphosphate (Glc1,6diP), serve as catalytic activators required in low micromolar concentration82. We show that theΨMP formation rate is the same irrespective of whether Glc1,6diP (a ...
Notably, the inhibition of Uridine diphosphate glycosyltransferases induced a transition in body color from green to yellow in the two-spotted spider mite. While the current investigation has not completely elucidated the mechanism underlying the pigmentation disparities between the two mite...
Uridine diphosphate glycosyltransferases (UGTs) are the key enzymes in glycosylation processes for decorating plant natural products with sugars. Crystallography, one of the powerful techniques for determining protein structures, was used as the main experimental technique and combined with biochemical methods...