Identify the uric acid transporter of [challenges] large-capacity, based on it, as contributing to the prevention and early treatment of inflammation-related diseases and uric acid transport-related disease, and evaluation of the inflammation-related disease predisposition and uric acid transport-related...
human urate transporter(UAT) and organic anion transporter(OAT1 and OAT3),there are responsible for uric acid secretion.Recently,also found that the one responsible for uric acid secretion into the extracellular,involved in the renal proximal tubule reabsorption of urate transporter protein-glucose ...
Medical Progress Uric Acid and Cardiovascular Risk 热度: 尿酸盐转运蛋白URAT1的表达纯化及单抗制备条件探索 热度: ,实用医院临床杂志,,,年,月第,,卷第,期 人尿酸盐转运蛋白,及其影响因素研究进展 ,,, 王英,,石桂秀,△ ,,, ,,福建中医药大学临床内科学风湿免疫专业,福建福州,,,厦门大学附属第一医院风湿免疫...
In conclusion, RSV may improve kidney inflammation through TLR4 and NLRP3 signaling pathways, and reduce the expression of UA transporter proteins in the kidney of insulinresistant mice, thereby reducing blood UA levels. 展开 关键词: GLUT9 RSV UA URAT1 inflammation ...
Uric acid (UA) is the end metabolic product of purine metabolism. Early on, UA was considered to be a metabolite with a certain antioxidant capacity. As research has progressed, other properties of UA have been explored, and its association with many dis
To investigate whether uric acid could regulate urate transporter 1 (URAT1) protein and activity level, we established uric acid nephropathy (UAN) rat model and detected their serum uric acid and URAT1 level with or without the treatment of allopurinol. Results here showed that allopurinol could re...
Lung cancer still ranks first in the mortality rate of cancer. Uric acid is a product of purine metabolism in humans. Its presence in the serum is controversial; some say that its high levels have a protective effect against tumors, others say the opposi
This Letter describes the discovery of a series of potent inhibitors of Human Uric Acid Transporter 1 (hURAT1). Lead generation and optimization via 3D pharmacophore analysis resulted in compound 41. With an IC50 of 33.7 nM, 41 also demonstrated good oral bioavailability in rat (74.8%) and di...
Serum Uric Acid XOR: Xanthine Oxidoreductase T2DM: Type 2 Diabetes Mellitus MetS: Metabolic Syndrome MAPK: Mitogen Activated Protein Kinase ROS: Reactive Oxygen Species VSMC: Vascular Smooth Muscle Cell CVD: CardioVascular Disease BC: Breast Cancer ...
Fig. 1. Uric acid excretion transporter. Herein, we review the development of URAT1 inhibitors in the past 10 years, including approved URAT1 inhibitors, URAT1 inhibitors under development in clinical trials, substances with URAT1 inhibitory effects, and conventional drugs with new uses. Compared with...