KIMIYOSHIDepartmentICHIDADepartmentNAOKODepartmentISOMURADepartmentKOSUKEDepartmentTSUJIDepartmentWileyPediatrics InternationalOhtsuka Y, Zaitsu M, Ichida K, Isomura N, Tsuji K, Sato T, Hamasaki Y. Human uric acid transporter 1 gene analysis in familial renal hypo-uricemia associated with exercise-induced ...
【摘要】尿酸,,,是嘌呤降解的最终产物,,,以上的原发性高尿酸血症是因肾脏对尿酸盐的排泄减少所致。人尿酸经肾脏转运时需依赖肾小管上皮细胞上的转运蛋白,而人尿酸盐转运蛋白,,,在尿酸盐重吸收过程中发挥重要作用。随着研究的不断深入,研究热点逐渐从,,,的结构和功能转为对基因突变及药物对其影响等。该文对...
Although the SLC22A12 (uric acid transporter 1) 258X allele is known to cause hypouricemia, the genotype frequency according to the serum uric acid (SUA) level has not been reported. This study investigated the SLC22A12 258WX frequency according to SUA levels among Japanese health-checkup ex...
This Letter describes the discovery of a series of potent inhibitors of Human Uric Acid Transporter 1 (hURAT1). Lead generation and optimization via 3D pharmacophore analysis resulted in compound 41. With an IC50 of 33.7 nM, 41 also demonstrated good oral bioavailability in rat (74.8%) and di...
Discovery of a flexible triazolylbutanoic acid as a highly potent uric acid transporter 1 (URAT1) inhibitor. Molecules 2016, 21, 1543... Tian,He,Liu,... 被引量: 3发表: 2016年 Aromatase inhibitors in the treatment of breast cancer. A number of inhibitors of estrogen synthesis are now becom...
Goldstein HS, Manowitz P (1993) Relation between serum uric acid and blood pressure in adolescents. Ann Hum Biol 20:423–431 ArticleCASPubMedGoogle Scholar Graessler J, Graessler A, Unger S, Kopprasch S, Tausche AK et al (2006) Association of the human urate transporter 1 with reduced re...
transporter(UAT) and organic anion transporter(OAT1 and OAT3),there are responsible for uric acid secretion.Recently,also found that the one responsible for uric acid secretion into the extracellular,involved in the renal proximal tubule reabsorption of urate transporter protein-glucose transporter ...
○ Mutations in proteins involved in the urate metabolism, especially xanthine oxidase (XO), urate transporter/channel (UAT), organic anion transporters 1 and 3 (OAT1 and OAT3) and urate transporter 1 (URAT1) View article Uric acid in metabolic syndrome: From an innocent bystander to a centra...
地址-邮编- 代理人信息 代理机构 特許業務法人謝国際特許商標事務所;謝 卓峰;元山 忠行;當別當 健司代理人 JIANGSUHENGRUIMEDICINECOLTD 摘要 - 法律状态 序号法律状态公告日法律状态法律状态信息 1--A621 + WRITTEN REQUEST FOR APPLICATION EXAMINATION C JP 2018515454A 496090860 JAPANESE INTERMEDIATE CODE: A621...
To investigate whether uric acid could regulate urate transporter 1 (URAT1) protein and activity level, we established uric acid nephropathy (UAN) rat model and detected their serum uric acid and URAT1 level with or without the treatment of allopurinol. Results here showed that allopurinol could re...